Document Detail

Effects of pentoxifylline and nitroprusside on guinea pig cochlear blood flow in relationship to various hematocrit values.
MedLine Citation:
PMID:  8858259     Owner:  NLM     Status:  MEDLINE    
To understand better the microcirculation in the inner ear in relation to blood viscosity, we examined the effects of pentoxifylline (PXF) and nitroprusside (NP) on cochlear blood flow (CBF) in healthy adult guinea pigs in relationship to various hematocrit (H1) values. There was no correlation between Ht value and the maximum decrease of mean blood pressure after PXF infusion, whereas there was a positive correlation between Ht and the maximum increase in CBF. No such relationship was found after NP infusion. A graph plot of each animal's blood oxygen transport capacity (i.e., Ht/blood viscosity) was found to have a convex form and to increase with a shift of the peak to a higher Ht area after PXF infusion. These findings indicate that a decrease in blood viscosity may improve CBF and increase oxygen transport capacity of blood.
Y Ohinata; K Makimoto; H Takahashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  253     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  345-50     Citation Subset:  IM    
Department of Otolaryngology, Saiseikai Nakatsu Hospital, Osaka, Japan.
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MeSH Terms
Blood Viscosity / drug effects*
Cochlea / blood supply*
Guinea Pigs
Microcirculation / drug effects
Nitroprusside / pharmacology*
Oxygen / metabolism
Pentoxifylline / pharmacology*
Regional Blood Flow / drug effects
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 6493-05-6/Pentoxifylline; 7782-44-7/Oxygen

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