| Effects of pentoxifylline on central hemodynamics in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 3810089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pentoxifylline, a xanthine derivative with vasoactive and hemorheologic properties, was studied in regard to effect on central hemodynamics in ten patients with congestive heart failure due to aortic or mitral valve disease, mainly in NYHA group III or IV. The drug was infused intravenously in a dose of 4 mg/kg b.w. during a stable hemodynamic situation after valve replacement. The heart rate, systemic blood pressure, central venous and pulmonary artery pressures and cardiac output were recorded, and the stroke volume, cardiac index and systemic vascular resistance were calculated. Significant increase in cardiac output from the baseline value of 4.92 l/min was found 5-10 min (+22.6%) and 25-30 min (+19.5%) after pentoxifylline infusion. Cardiac index similarly increased from baseline, 2.73 dsc-5 (+22.3 and +18.3, respectively). The systemic vascular resistance showed significant decrease at the same intervals (-20.6 and -15.5%). The heart rate and stroke volume were significantly increased after 5-10 min. The systemic mean blood pressure and the pulmonary artery and central venous pressures showed no significant changes. There were no adverse effects of pentoxifylline. |
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Authors:
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O Nordhus; S Ekeström; L Liljeqvist |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of thoracic and cardiovascular surgery Volume: 20 ISSN: 0036-5580 ISO Abbreviation: Scand J Thorac Cardiovasc Surg Publication Date: 1986 |
Date Detail:
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Created Date: 1987-03-18 Completed Date: 1987-03-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121343 Medline TA: Scand J Thorac Cardiovasc Surg Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects Cardiac Output / drug effects Female Heart Failure / drug therapy* Hemodynamics / drug effects* Humans Male Middle Aged Myocardial Contraction / drug effects Pentoxifylline / therapeutic use* Stroke Volume / drug effects Theobromine / analogs & derivatives* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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6493-05-6/Pentoxifylline; 83-67-0/Theobromine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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