Document Detail

Effects of pentastarch and albumin infusion on cardiorespiratory function and coagulation in patients with severe sepsis and systemic hypoperfusion.
MedLine Citation:
PMID:  2468447     Owner:  NLM     Status:  MEDLINE    
Twenty consecutive patients with severe sepsis were randomized to fluid challenge with 5% albumin or 10% low MW hydroxyethyl starch (pentastarch) solutions. Fluid challenge was administered iv as 250 ml of test colloid every 15 min until the pulmonary artery wedge pressure (WP) was greater than or equal to 15 mm Hg or a maximum dose of 2000 ml was infused. Hemodynamic, respiratory, and coagulation profiles were measured before and after fluid infusion. The amount of colloid required to achieve a WP of 15 mm Hg was comparable between groups. Both colloid infusions resulted in similar increases in cardiac output, stroke output, and stroke work. The effect of fluid infusion with pentastarch on coagulation was not significantly different from albumin, although pentastarch was associated with a 45% decrease in factor VIII:c. We conclude that pentastarch is equivalent to albumin for fluid resuscitation of patients with severe sepsis.
E C Rackow; C Mecher; M E Astiz; M Griffel; J L Falk; M H Weil
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Critical care medicine     Volume:  17     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-07     Completed Date:  1989-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-8     Citation Subset:  AIM; IM    
Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064.
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MeSH Terms
Aged, 80 and over
Albumins / therapeutic use*
Bacterial Infections / mortality,  physiopathology,  therapy*
Blood Circulation / drug effects
Blood Coagulation / drug effects*
Fluid Therapy / methods*
Hemodynamics / drug effects*
Hetastarch / therapeutic use*
Middle Aged
Random Allocation
Respiration / drug effects*
Respiratory Function Tests
Starch / analogs & derivatives*
Reg. No./Substance:
0/Albumins; 9005-25-8/Starch; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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