| Effects of pentagastrin, histamine, carbamylcholine and catecholamines on gastric secretion, motility and emptying in the rat. | |
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MedLine Citation:
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PMID: 7150367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We developed a simplified method for the simultaneous measurement of gastric secretion and gastric motility in the rat. By using this method, we investigated the actions of pentagastrin, histamine, carbamylcholine and catecholamines on the stomach. Carbamylcholine stimulated acid secretion and induced contraction of the stomach, but norepinephrine tended to inhibit acid secretion and induced relaxation of the stomach. Histamine induced relaxation first and then contraction after 2-5 min. Pentagastrin induced a relaxation that did not show dose dependence, but tachyphylaxis. Isoproterenol, which stimulated acid secretion in our experiments, induced relaxation of the stomach in a dose-dependent manner. We also investigated the relationship between gastric motility and gastric emptying. Carbamylcholine caused an enhancement of gastric emptying, but isoproterenol caused its suppression. Pentagastrin, histamine and norepinephrine did not affect gastric emptying. As shown in the results of our experiments, carbamylcholine caused stimulation of acid secretion, contraction of the stomach, and enhancement of gastric emptying. However, other secretagogues did not always induce contraction of the stomach or increase gastric emptying. |
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Authors:
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S Tani; N Muto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical pharmacology Volume: 31 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1983-01-27 Completed Date: 1983-01-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3475-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / pharmacology* Catecholamines / pharmacology* Dose-Response Relationship, Drug Gastric Emptying / drug effects Gastric Juice / secretion Gastrointestinal Motility / drug effects Histamine / pharmacology* Male Muscle Contraction / drug effects Pentagastrin / pharmacology* Rats Rats, Inbred Strains Stomach / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 51-45-6/Histamine; 51-83-2/Carbachol; 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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