Document Detail

Effects of pentagastrin, histamine, carbamylcholine and catecholamines on gastric secretion, motility and emptying in the rat.
MedLine Citation:
PMID:  7150367     Owner:  NLM     Status:  MEDLINE    
We developed a simplified method for the simultaneous measurement of gastric secretion and gastric motility in the rat. By using this method, we investigated the actions of pentagastrin, histamine, carbamylcholine and catecholamines on the stomach. Carbamylcholine stimulated acid secretion and induced contraction of the stomach, but norepinephrine tended to inhibit acid secretion and induced relaxation of the stomach. Histamine induced relaxation first and then contraction after 2-5 min. Pentagastrin induced a relaxation that did not show dose dependence, but tachyphylaxis. Isoproterenol, which stimulated acid secretion in our experiments, induced relaxation of the stomach in a dose-dependent manner. We also investigated the relationship between gastric motility and gastric emptying. Carbamylcholine caused an enhancement of gastric emptying, but isoproterenol caused its suppression. Pentagastrin, histamine and norepinephrine did not affect gastric emptying. As shown in the results of our experiments, carbamylcholine caused stimulation of acid secretion, contraction of the stomach, and enhancement of gastric emptying. However, other secretagogues did not always induce contraction of the stomach or increase gastric emptying.
S Tani; N Muto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  31     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3475-81     Citation Subset:  IM    
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MeSH Terms
Carbachol / pharmacology*
Catecholamines / pharmacology*
Dose-Response Relationship, Drug
Gastric Emptying / drug effects
Gastric Juice / secretion
Gastrointestinal Motility / drug effects
Histamine / pharmacology*
Muscle Contraction / drug effects
Pentagastrin / pharmacology*
Rats, Inbred Strains
Stomach / physiology*
Reg. No./Substance:
0/Catecholamines; 51-45-6/Histamine; 51-83-2/Carbachol; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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