| Effects of penicillin-binding protein 4 overproduction in Staphylococcus aureus. | |
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MedLine Citation:
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PMID: 9158759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pbp4 gene of a Staphylococcus aureus strain selected stepwise in vitro for growth on increasing concentrations of penicillin and of its susceptible parent strain showed overall identity except in the promoter region. In the mutant a deletion upstream of the pbp4 structural gene removed 90 nucleotides (nt) that were framed by a 12 nt inverted repeat. This deletion occurred in step 4 of the in vitro selection procedure and was paralleled by a significant increase in the penicillin-binding protein 4 (PBP4) production. The in vitro step selected mutant showed a remarkable increase in the cross-linking of the peptidoglycan compared to its parent. This was linked to morphological changes in the appearance of the cells, which were surrounded by a very thick and fuzzy cell wall. |
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Authors:
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U U Henze; M Roos; B Berger-Bächi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microbial drug resistance (Larchmont, N.Y.) Volume: 2 ISSN: 1076-6294 ISO Abbreviation: Microb. Drug Resist. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-06-17 Completed Date: 1997-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508567 Medline TA: Microb Drug Resist Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-9 Citation Subset: IM |
Affiliation:
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Institute of Medical Microbiology, University of Zürich, Switzerland. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/X87104; X87105; X91786 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Bacterial Proteins* Base Sequence Carrier Proteins / biosynthesis* Cell Wall / chemistry, ultrastructure Hexosyltransferases* Humans Methicillin Resistance / genetics* Microscopy, Electron Molecular Sequence Data Muramoylpentapeptide Carboxypeptidase / biosynthesis* Mutation Penicillin-Binding Proteins Penicillins / metabolism* Peptidyl Transferases* Staphylococcal Infections / microbiology Staphylococcus aureus / metabolism*, ultrastructure Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Carrier Proteins; 0/Penicillin-Binding Proteins; 0/Penicillins; EC 2.3.2.12/Peptidyl Transferases; EC 2.4.1.-/Hexosyltransferases; EC 3.4.17.8/Muramoylpentapeptide Carboxypeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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