Document Detail


Effects of pattern of ventilation on pulmonary metabolism and mechanics.
MedLine Citation:
PMID:  1089369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of three patterns of mechanical ventilation on pulmonary mechanics, lung phospholipid and surface activity were studied in the normal closed-chest dog. The patterns were continuous mechanical ventilation with: 1) tidal volume (VT)=15 ml/kg; 2) VT=15 ml/kg with 10 cm H2O positive end-expiratory pressure (PEEP); 3) VT=50 ml/kg. THE DOGS IN EACH GROUP WERE VENTILATED FOR 24 HOURS, WITH CAREFUL ATTENTION PAID TO MAINTENANCE OF NORMAL BLOOD GASES, FLUID BALANCE, AND CARDIAC OUTPUT. The animals were sacrificed and the lungs studied to determine pressure-volume curves, dry lung weight/wet lung weight ratios, phospholpid contents and surface activities. The results were compared with control values in acutely sacrificed unventilated dogs. No significant change from controls was found with any pattern of ventilation employed with the exception of the tendency for lungs ventilated with PEEP to retain fluid (decreased dry lung weight/wet lung weight ratio).
Authors:
D Thornton; H Ponhold; J Butler; T Morgan; F W Cheney
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  42     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-04-08     Completed Date:  1975-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-10     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Carbon Dioxide / blood
Cardiac Output
Dogs
Intermittent Positive-Pressure Breathing
Lung / analysis,  metabolism*,  physiology
Male
Manometry
Oxygen / blood
Partial Pressure
Phosphatidylcholines / analysis
Phospholipids / analysis
Plethysmography
Positive-Pressure Respiration
Pressure
Pulmonary Surfactants*
Respiration, Artificial*
Spirometry
Surface Tension
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phospholipids; 0/Pulmonary Surfactants; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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