Document Detail


Effects of passive hyperthermia versus exercise-induced hyperthermia on immune responses: hormonal implications.
MedLine Citation:
PMID:  17823084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: The plasma levels of catecholamines were increased only during E, prolactin was increased only during PH, and cortisol was increased in both E and PH. Only the exercise caused a mobilization of blood leukocytes and leukocyte subsets. The INF-gamma and TNF-alpha production by PHA- and LPS-stimulated blood, respectively, were inhibited in a substantial way in both E and PH compared to control when Tre reached 39 degrees C. Only LPS-induced IL-10 production was enhanced during the exercise. The effects of the challenges were increased with 39 degrees C compared to 38.5 degrees C.
CONCLUSIONS: Catecholamines play a major role in the mobilization of immunocompetent cells and the production of IL-10 during exercise. Prolactin and catecholamines have adverse role on the immune response, whereas cortisol exerts similar effects during both trials. The consequence could be a protection against inflammatory overshooting.
Authors:
Chantal Jimenez; Bruno Melin; Gustave Savourey; Jean-Claude Launay; Antonia Alonso; Jacques Mathieu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-09-07
Journal Detail:
Title:  European cytokine network     Volume:  18     ISSN:  1148-5493     ISO Abbreviation:  Eur. Cytokine Netw.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-01-08     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9100879     Medline TA:  Eur Cytokine Netw     Country:  France    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Affiliation:
Département des Facteurs Humains, Centre de Recherches du Service de Santé des Armées, 24 avenue des Maquis du Grésivaudan, 38702 La Tronche Cedex, France. chantal.jimenez@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Temperature / physiology
Catecholamines / blood,  immunology
Cytokines / biosynthesis*,  blood
Exercise / physiology*
Hormones / biosynthesis*,  blood
Hot Temperature / adverse effects
Humans
Hydrocortisone / biosynthesis,  blood
Hyperthermia, Induced / adverse effects
Interferon-gamma / biosynthesis,  blood
Interleukin-10 / biosynthesis,  blood
Leukocytes / immunology,  secretion
Lipopolysaccharides / pharmacology
Physical Endurance / physiology
Phytohemagglutinins / pharmacology
Prolactin / biosynthesis,  blood
Research Design
Stress, Physiological / blood*,  immunology*
Tumor Necrosis Factor-alpha / biosynthesis,  blood
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Cytokines; 0/Hormones; 0/Lipopolysaccharides; 0/Phytohemagglutinins; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 50-23-7/Hydrocortisone; 82115-62-6/Interferon-gamma; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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