Document Detail


Effects of particulate matter on cytokine production in vitro: a comparative analysis of published studies.
MedLine Citation:
PMID:  18302048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years evidence has accumulated indicating that airborne particles cause adverse health effects. To understand the underlying mechanisms, a multitude of in vitro studies have been performed focusing on inflammatory responses, especially cytokine production. However, the diversity of studies renders it difficult to determine which results are consistent and which exposures most effective. The present review thus aimed to perform a comparative analysis of the available data. Forty-nine studies dealing with in vitro effects of particles on cytokine production in bronchial epithelial or related cells and monocytes/macrophages were included. Twenty-eight studies investigated epithelial cells and could be categorized according to specific combinations of exposure level and time, and 27 dealt with monocytes/macrophages. Eight studies provided further data using non-compatible exposure modes. The most common finding was that particles significantly induced cytokine production in both epithelial cells and monocytes/macrophages at concentrations of 50-100 microg/mL and exposure times of 9-24 h. The effects did not appear to be significantly different between cell or particle types. There were virtually no effects reported below 10 microg/mL, but these levels were used in only a few studies. Thus, the available data demonstrate that cytokine measurements are sensitive enough to assess cell activation after particle exposure in vitro, yielding relatively consistent results across cell types. However, since the majority of data refers to high particle load compared to in vivo conditions, future studies should consider more sensitive assays, multivariate panels describing the cell's regulatory state, interactions between cell types, and second-line outcome measures that are close to clinically observed effects.
Authors:
S Mitschik; R Schierl; D Nowak; R A Jörres
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Inhalation toxicology     Volume:  20     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-414     Citation Subset:  IM    
Affiliation:
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Culture Media, Conditioned / pharmacology
Cytokines / genetics,  metabolism*
Dose-Response Relationship, Drug
Gene Expression / drug effects
Humans
Macrophages / drug effects*,  metabolism,  pathology
Mice
Monocytes / drug effects*,  metabolism,  pathology
Particulate Matter / toxicity*
PubMed
Rats
Respiratory Mucosa / drug effects*,  metabolism,  pathology
Chemical
Reg. No./Substance:
0/Culture Media, Conditioned; 0/Cytokines; 0/Particulate Matter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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