| Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice. | |
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MedLine Citation:
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PMID: 22882852 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Hilar cholangiocarcinoma is a malignant tumor that is difficult to cure. BACKGROUNDThe aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice. METHODS: Eight minipigs were made into chronic obstructive jaundice models. United semi-hepatectomy, which imitates extended radical surgery for treatment of hilar cholangiocarcinoma, was then performed. The eight minipigs were randomly divided into groups A and B (n = 4 minipigs each). PPVA was performed in Group A but not in Group B. The effects of flow-controlled PPVA on live regeneration after hepatectomy were observed for 30 days after hepatectomy. RESULTS: The portal vein PO(2) at the immediate time point and on postoperative day 30 was higher in Group A ((47.33 ± 2.43) and (48.50 ± 4.44) mmHg) than in Group B ((35.38 ± 4.06) and (35.55 ± 2.55) mmHg respectively, all P < 0.01). The mitotic index of liver cells on postoperative days 14 and 21 was higher in Group A (12.55% ± 2.85% and 15.25% ± 1.99% respectively) than in Group B (6.85% ± 2.10% and 11.88% ± 1.15% respectively, all P < 0.05). The regeneration rate of residual liver on postoperative days 14 and 21 was higher in Group A (24.56% ± 6.15% and 70.63% ± 9.83% respectively) than in Group B (11.96% ± 5.43% and 44.92% ± 7.42% respectively, P < 0.05 and P < 0.01 respectively). CONCLUSION: Flow-controlled PPVA can promote liver regeneration after hepatectomy and prevent liver failure in minipigs with chronic obstructive jaundice. |
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Authors:
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Yong-Liang Chen; Wen-Bin Chen; Yun-Yan Wan; Wen-Gang Li; Zhi-Qiang Huang; Xiao-Tong Wu; Jie Yang; Li Yang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 125 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-08-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 2302-5 Citation Subset: IM |
Affiliation:
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Institute of Hepatobiliary Surgery, General Hospital of People's Liberation Army, Beijing 100853, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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