| Effects of partial ileal bypass on the progression of atherosclerotic lesions in WHHL rabbits. | |
| | |
MedLine Citation:
|
PMID: 3827983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
At age of 40 weeks, 9 WHHL rabbits were necropsied as a baseline control group for evaluating aortic and coronary atherosclerosis. An additional 18 WHHL rabbits of the same age underwent either a partial ileal bypass (PIB) or a sham operation. Serum cholesterol concentrations were significantly lower in PIB rabbits than in sham-operated rabbits, mean postsurgical values being 7.9 +/- 2.3 mmol/l and 13.2 +/- 2.4 mmol/l, respectively. This effect was mainly due to a lower LDL-cholesterol concentration. Serum triglycerides remained unaffected. Thirty weeks after surgery the PIB and sham rabbits were necropsied and atherosclerosis was evaluated. Progression of atherosclerotic plaque size in the sham group was most prominent in the aortic arch. PIB largely prevented this progression. The frequency of plaque complications in the aortic arch also increased in the sham groups. Here, no significant improvement was found in the PIB group. Extensive examination of the heart showed some affected coronary arteries in every 40-week-old WHHL rabbit. Progression of coronary atherosclerosis during the postsurgical period was small in both sham and PIB groups. However, while PIB did not affect the plaque size, it significantly reduced the number of coronary arteries affected. |
| | |
Authors:
|
J L Van Niekerk; T Hendriks; H H De Boer |
Related Documents
:
|
7213023 - Lipoprotein uptake in perfused arteries: inhibition by 7-ketocholesterol. 14645853 - Mutation of mef2a in an inherited disorder with features of coronary artery disease. 1180463 - Intracavernous aneurysm with isolated 6th nerve palsy. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Atherosclerosis Volume: 63 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1987 Feb |
Date Detail:
|
Created Date: 1987-04-10 Completed Date: 1987-04-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 225-30 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta, Thoracic / pathology Aortic Diseases / blood, pathology Arteriosclerosis / blood, pathology* Cholesterol / blood Coronary Artery Disease / blood, pathology Coronary Vessels / pathology Jejunoileal Bypass* Lipoproteins / blood* Rabbits Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Italian multicenter study of reversible cerebral ischemic attacks. Part 5. Risk factors and cerebral...
Next Document: Vitamin B6 and coronary artery disease. Epidemiological observations and case studies.