Document Detail


Effects of parkinsonism on health status in welding exposed workers.
MedLine Citation:
PMID:  21724446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies suggest that welders frequently display parkinsonian signs, such as bradykinesia and tremor. Demonstrating that these parkinsonian findings are associated with reductions in quality of life (QoL) or health status could have important repercussions for worker safety and performance.
METHODS: Subjects included 394 active workers exposed to welding fumes and evaluated for parkinsonism by movement disorders experts in a worksite-based epidemiology study. Subjects were diagnosed with parkinsonism if the Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) score was ≥15. All subjects completed a Parkinson's disease (PD) symptom questionnaire and the PDQ39, a widely used QoL and health status measure for PD.
RESULTS: Total PDQ39 score and all subscores were greater in welders with parkinsonism than welders without parkinsonism, with the most significant differences observed for mobility, emotional well-being, and activities of daily living (ADL's). The PDQ39 scores for welding exposed workers with parkinsonism were similar to scores seen in a group of early PD patients.
CONCLUSION: Parkinsonism in active, welding exposed workers is associated with reductions in health status and QoL affecting a broad range of categories and within the range seen in early PD.
Authors:
Rachel C Harris; Jessica I Lundin; Susan R Criswell; Angela Hobson; Laura M Swisher; Bradley A Evanoff; Harvey Checkoway; Brad A Racette
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-02
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  17     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2012-02-07     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Female
Health Status*
Humans
Male
Middle Aged
Occupational Diseases / epidemiology*,  etiology
Occupational Exposure / adverse effects*
Parkinsonian Disorders / epidemiology*,  etiology
Prevalence
Quality of Life*
Welding*
Grant Support
ID/Acronym/Agency:
5T32NS007205-2/NS/NINDS NIH HHS; K24 ES017765/ES/NIEHS NIH HHS; K24 ES017765/ES/NIEHS NIH HHS; K24 ES017765-01A2/ES/NIEHS NIH HHS; P42 ES01696/ES/NIEHS NIH HHS; R01 ES013743/ES/NIEHS NIH HHS; R01 ES013743/ES/NIEHS NIH HHS; R01 ES013743-01A2/ES/NIEHS NIH HHS; R01 ES013743-03S1/ES/NIEHS NIH HHS; R01ES013743-02S1/ES/NIEHS NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
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