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Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis.
MedLine Citation:
PMID:  23379728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To assess the impact of household smoking and palivizumab prophylaxis on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm (32-35 weeks' gestational age) infants. Methods: Familial smoking and other RSV risk factor data from the FLIP, FLIP-2 and IMpact studies and datasets from France, Germany and Italy, together with palivizumab prophylaxis data from the FLIP-2 and IMpact studies, were analysed using cross-correlation and Bayesian meta-analytical modelling employing Markov Chain Monte Carlo (MCMC) sampling. Results: There were 2.35 times (95% CI 1.37 to 4.02) as many hospitalisations amongst infants from smoking compared with those from non-smoking families. Among non-prophylaxed infants, there were 2.53 times (95% CI 1.27 to 4.94) as many RSV hospitalisations from smoking than from non-smoking families and that excess hospitalisation was reduced to 1.03 times (95% CI 0.38 to 2.99) amongst prophylaxed infants. Familial smoking correlates significantly (p<0.01) with other RSV risk factors: positive correlation with number of school-age siblings, history of family atopy, family wheeze, and gestational age; negative correlation with birth weight and breast feeding. Conclusions: Late-preterm infants from smoking families appear to be at heightened risk for severe RSV infection requiring hospitalisation of which the risk may be reduced with RSV prophylaxis.
Authors:
Xavier Carbonell-Estrany; John R Fullarton; Katherine L Gooch; Pamela G Vo; Jose Figueras-Aloy; Marcello Lanari; Jean-Bernard Gouyon; Johannes G Liese
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Senior Consultant, Neonatology Service, Hospital Clínic, Institut Clínic de Ginecologia Obstetricia I Neonatologia, Barcelona, Spain.
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