Document Detail

Effects of parathyroidectomy on blood pressure in spontaneously hypertensive rats.
MedLine Citation:
PMID:  3808149     Owner:  NLM     Status:  MEDLINE    
The long-term effects of parathyroidectomy (PTX) on blood pressure, intravascular volume, pressor hormones, and on acute vascular effects of intravenous parathyroid hormone (PTH) were evaluated in spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WK) rats. PTX or sham operation (CO) were done at 4-5 weeks of age, and a high calcium diet was offered to PTX rats to study them at eucalcemic calcium levels. The cardiovascular effects of PTX, determined after 11-13 weeks, were qualitatively similar in SH and WK rats: mean arterial blood pressure (conscious unrestrained rats) was lower, intravascular volume was higher, total body sodium was slightly higher, and plasma angiotensin II or norepinephrine levels were not different from CO groups. The acute hypotensive and chronotrophic effect of intravenous PTH was unchanged in PTX groups. When parathyroid intact SH rats and PTX SH rats were both examined on an 1.6% Ca diet, blood pressure was significantly lower in PTX than in parathyroid-intact SH rats. The results are compatible with the hypothesis that PTH has a permissive action on blood pressure maintenance in eucalcemic SH and WK rats by mechanisms unrelated to volume status or circulating pressor hormone concentrations.
J F Mann; A Wieçek; J Bommer; U Ganten; E Ritz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  45     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1987  
Date Detail:
Created Date:  1987-03-19     Completed Date:  1987-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
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MeSH Terms
Blood Chemical Analysis
Blood Pressure*
Blood Volume
Calcium, Dietary / administration & dosage
Parathyroid Glands / physiology*,  surgery
Parathyroid Hormone / physiology
Rats, Inbred SHR / physiology*
Rats, Inbred Strains / physiology*
Rats, Inbred WKY
Reg. No./Substance:
0/Calcium, Dietary; 0/Parathyroid Hormone

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