Document Detail


Effects of parathyroid hormone and related polypeptides on the heart and coronary circulation of dogs.
MedLine Citation:
PMID:  6167798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of parathyroid hormone and related polypeptides on the heart were examined using the canine heart-lung preparation supported by a donor. Synthetic bovine parathyroid hormone (PTH) containing 34 amino acids [PTH-(1--34)] and natural bovine PTH containing 84 amino acids [PTH-(1--84)] showed slight positive chronotropic and inotropic action and prominent coronary vasodilator action. The effects of the two compounds were very similar. The cardiac stimulatory action was not blocked by pindolol. The coronary vasodilation occurred without increase in the myocardial oxygen consumption, suggesting that it is due to a direct action on the coronary vasculature. All effects occurred soon after intra-arterial injection, lasted only about 20 min, and were not accompanied by changes in plasma Ca and Pi levels. Fragments of PTH, PTH-(24--34) containing 11 amino acids. PTH-(24--28) containing 5 amino acids, and PTH-(25--27) containing 3 amino acids showed very weak transient coronary dilatory action without cardiac stimulatory effects.
Authors:
K Hashimoto; Y Nakagawa; T Shibuya; H Satoh; T Ushijima; S Imai
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  3     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  668-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Calcium / blood
Coronary Circulation / drug effects*
Dogs
Female
Heart / drug effects*
Heart Rate / drug effects
Male
Myocardium / metabolism
Oxygen Consumption / drug effects
Parathyroid Hormone / pharmacology*
Peptide Fragments / pharmacology*
Phosphates / blood
Teriparatide
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Peptide Fragments; 0/Phosphates; 52232-67-4/Teriparatide; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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