Document Detail

Effects of the parasiticide ivermectin on the cladoceran Daphnia magna and the green alga Pseudokirchneriella subcapitata.
MedLine Citation:
PMID:  17624408     Owner:  NLM     Status:  MEDLINE    
Although widely used for the treatment of endo- and ectoparasites in livestock and pets, very few data on chronic effects on aquatic organisms are available for the parasiticide ivermectin. In the present study, toxicity of ivermectin to two freshwater organisms, the cladoceran Daphnia magna and the green alga Pseudokirchneriella subcapitata was investigated. For D. magna, a mean LC(50) 48 h of 5.7 ngl(-1) was derived from 10 acute tests. Chronic toxicity of ivermectin to D. magna was extremely high: with 0.001 and 0.0003 ngl(-1), respectively, nominal LOEC and NOEC based on growth and reproduction were far below the analytical limit of detection for this compound. P. subcapitata was considerably less sensitive to ivermectin than D. magna. For both growth rate and yield, EC(50) was >4,000 microgl(-1), LOEC was 1,250 microgl(-1) and NOEC 391microgl(-1). In view of the high toxicity to D. magna, the use of ivermectin might pose a risk to local aquatic ecosystems. Further studies should be carried out to investigate the effects of ivermectin and its degradation products on pelagic and benthic freshwater invertebrates.
Jeanne Garric; Bernard Vollat; Karen Duis; Alexandre Péry; Thomas Junker; Maria Ramil; Guido Fink; Thomas A Ternes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-10
Journal Detail:
Title:  Chemosphere     Volume:  69     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  903-10     Citation Subset:  IM    
Laboratoire d' écotoxicologie, Cemagref, 3bis quai Chauveau, 69336 Lyon, CP 220, Cedex 09, France.
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MeSH Terms
Acute Toxicity Tests
Algae, Green / drug effects*,  growth & development
Antiparasitic Agents / toxicity*
Daphnia / drug effects*,  growth & development
Ivermectin / toxicity*
Lethal Dose 50
Reproduction / drug effects
Risk Assessment
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Antiparasitic Agents; 0/Water Pollutants, Chemical; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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