| Effects of the parasiticide ivermectin on the cladoceran Daphnia magna and the green alga Pseudokirchneriella subcapitata. | |
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MedLine Citation:
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PMID: 17624408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although widely used for the treatment of endo- and ectoparasites in livestock and pets, very few data on chronic effects on aquatic organisms are available for the parasiticide ivermectin. In the present study, toxicity of ivermectin to two freshwater organisms, the cladoceran Daphnia magna and the green alga Pseudokirchneriella subcapitata was investigated. For D. magna, a mean LC(50) 48 h of 5.7 ngl(-1) was derived from 10 acute tests. Chronic toxicity of ivermectin to D. magna was extremely high: with 0.001 and 0.0003 ngl(-1), respectively, nominal LOEC and NOEC based on growth and reproduction were far below the analytical limit of detection for this compound. P. subcapitata was considerably less sensitive to ivermectin than D. magna. For both growth rate and yield, EC(50) was >4,000 microgl(-1), LOEC was 1,250 microgl(-1) and NOEC 391microgl(-1). In view of the high toxicity to D. magna, the use of ivermectin might pose a risk to local aquatic ecosystems. Further studies should be carried out to investigate the effects of ivermectin and its degradation products on pelagic and benthic freshwater invertebrates. |
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Authors:
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Jeanne Garric; Bernard Vollat; Karen Duis; Alexandre Péry; Thomas Junker; Maria Ramil; Guido Fink; Thomas A Ternes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-10 |
Journal Detail:
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Title: Chemosphere Volume: 69 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2008-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: 903-10 Citation Subset: IM |
Affiliation:
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Laboratoire d' écotoxicologie, Cemagref, 3bis quai Chauveau, 69336 Lyon, CP 220, Cedex 09, France. garric@lyon.cemagref.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Toxicity Tests Algae, Green / drug effects*, growth & development Animals Antiparasitic Agents / toxicity* Daphnia / drug effects*, growth & development Ivermectin / toxicity* Lethal Dose 50 Reproduction / drug effects Risk Assessment Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antiparasitic Agents; 0/Water Pollutants, Chemical; 70288-86-7/Ivermectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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