| Effects of paraquat on the freshwater fish Channa punctata (Bloch): non-enzymatic antioxidants as biomarkers of exposure. | |
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MedLine Citation:
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PMID: 16502204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paraquat is a quaternary herbicide widely used for broadleaf weed control, which has been known to be a highly toxic compound for humans and animals. Therefore, analysis and development of biomarkers of exposure are undoubtedly valuable in evaluating the toxicity of paraquat contaminated water bodies. The effect of a single exposure of paraquat (1 ppm) for 24 h on various non-enzymatic antioxidants was studied in freshwater fish Channa punctata (Bloch). The levels of the reduced glutathione were significantly reduced in the liver and gill of exposed fish. The total and protein thiol levels were increased in all the tissues of the exposed fish. The non-protein thiol levels were reduced in liver and gill. The levels of ascorbic acid increased in liver. The uric acid level increased significantly in kidney and decreased significantly in gill of the exposed fish. The findings of the present investigation demonstrate the oxidative-stress-inducing potential of the herbicide paraquat in fish. This work indicated the possibility of using non-enzymatic antioxidants as biomarkers of exposure to environmental contamination and subsequent validation as a sensitive system for biomonitoring and ecotoxicological risk assessment. |
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Authors:
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Suhel Parvez; Sheikh Raisuddin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-24 |
Journal Detail:
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Title: Archives of environmental contamination and toxicology Volume: 50 ISSN: 0090-4341 ISO Abbreviation: Arch. Environ. Contam. Toxicol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0357245 Medline TA: Arch Environ Contam Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 392-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Magdeburg, Leipziger Str. 44, D-39120, Magdeburg, Germany. drsuhelparvez@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism* Ascorbic Acid / metabolism Biological Markers Environmental Monitoring Fresh Water Gills / metabolism Glutathione / metabolism Kidney / metabolism Lipid Peroxidation / drug effects Liver / metabolism Paraquat / toxicity* Perciformes / metabolism* Sulfhydryl Compounds / metabolism Uric Acid / metabolism Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Sulfhydryl Compounds; 0/Water Pollutants, Chemical; 4685-14-7/Paraquat; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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