Document Detail


Effects of pancreas-kidney transplantation on diabetic retinopathy.
MedLine Citation:
PMID:  15819813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of pancreas transplantation (PTx) on diabetic retinopathy (DR) are still debated. We studied the course of DR in 48 patients (age: 40 +/- 7 years; males/females 26/22, body mass index (BMI): 23.0 +/- 2.4 kg/m2, duration of diabetes: 24 +/- 8 years) bearing a successful PTx (combined with a kidney). Follow-up ranged 6-60 months (median: 17 months). Before transplantation, according to the Eurodiab Study classification, 12 patients (25%) had nonproliferative retinopathy (NPDR; mild, moderate or severe), and 36 patients (75%) had laser-treated and/or proliferative retinopathy (LT/PDR). During the follow-up, in the NPDR group improvement/deterioration was defined as regression/progression to a lower/higher retinopathy grade; in the LT/PTD group, stabilization was defined as no new neo-vessel formation or development of new lesions requiring laser-treatment. In the NPDR group, five (41.7%) patients improved of one or more lesion grading, three (25%) patients showed no change, and four (33.3%) patients progressed of one grade. In the LT/PDR group, the post-transplant data were: stabilization in 35 (97%) patients, and worsening in one (3%) patient. The number of improved/stabilized patients was significantly higher in the transplanted than in a control group of nontransplanted type 1 diabetic patients. In conclusion, despite a relatively short follow-up period, successful PTx in our cohort of patients was associated with improvement and/or stabilization of DR in the majority of recipients.
Authors:
Rosa Giannarelli; Alberto Coppelli; Mariasole Sartini; Michele Aragona; Ugo Boggi; Fabio Vistoli; Gaetano Rizzo; Stefano Del Prato; Franco Mosca; Piero Marchetti
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  18     ISSN:  0934-0874     ISO Abbreviation:  Transpl. Int.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism-Metabolic Unit, University of Pisa, I-56121, Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Cohort Studies
Diabetes Mellitus, Type 1 / blood,  surgery
Diabetic Nephropathies / blood,  surgery
Diabetic Retinopathy / therapy*
Female
Hemoglobin A, Glycosylated / metabolism
Humans
Islets of Langerhans Transplantation*
Kidney Transplantation*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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