Document Detail

Effects of pH and dissolved CO(2) level on simultaneous production of 2,3-butanediol and succinic acid using Klebsiella pneumoniae.
MedLine Citation:
PMID:  23010216     Owner:  NLM     Status:  Publisher    
The influences of pH and dissolved CO(2) level on the regulation of growth and formation of catabolic end products have been investigated in Klebsiella pneumoniae. With increasing CO(2) levels, there were no apparent changes in 2,3-butanediol production but succinic acid productions were enhanced significantly. A novel strategy for co-production of 2,3-butanediol and succinic acid using K. pneumoniae was developed by controlling pH and dissolved CO(2) concentration in fermentation medium. Under the optimum condition, maximal 77.1gl(-1) 2,3-butanediol and 28.7gl(-1) succinic acid were obtained after 60h of fed-batch fermentation, giving a 2,3-butanediol+succinic acid yield of 1.03molmol(-1) glucose. This type of fermentation producing two commercial interests at the same fermentation process might be considered for a promising biological production process which will decrease the production cost by sharing the operation and recovery cost.
Ke-Ke Cheng; Jing Wu; Gen-Yu Wang; Wen-Ying Li; Jie Feng; Jian-An Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-5
Journal Detail:
Title:  Bioresource technology     Volume:  -     ISSN:  1873-2976     ISO Abbreviation:  Bioresour. Technol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9889523     Medline TA:  Bioresour Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China.
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