Document Detail


Effects of ozone and sulfuric acid aerosol on gas trapping in the guinea pig lung.
MedLine Citation:
PMID:  3701878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four groups of 20 guinea pigs were sequentially exposed by inhalation to either air followed by sulfuric acid aerosol, ozone followed by sulfuric acid aerosol, ozone followed by air, or air followed by air to determine whether ozone preexposure sensitizes guinea pigs to the airway constrictive effects of sulfuric acid aerosol. All first exposures to ozone or air were 2 h in duration; all second exposures to sulfuric acid or air were for 1 h. All ozone and sulfuric acid exposures were 0.8 ppm and 12 mg/m3, respectively. Animals were observed for respiratory distress during exposure, and excised lungs were quantitated for trapped gas and wet/dry ratios. None of the guinea pigs developed dyspnea, and wet/dry ratios were not altered. Ozone significantly (p less than 0.05) increased trapped gas volumes, which were 44% (ozone-acid) to 68% (ozone-air) greater than in the air-air group. Trapped gas volume was 23% greater in the ozone-acid group than in the air-acid group, but the difference was not statistically significant (p less than 0.20). Thus, ozone increased gas trapping but did not significantly sensitize guinea pigs to the bronchoconstrictive action of sulfuric acid.
Authors:
S A Silbaugh; J L Mauderly
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  18     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-12     Completed Date:  1986-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Animals
Female
Gases / analysis*
Guinea Pigs
Kinetics
Lung / drug effects*,  pathology
Male
Ozone / administration & dosage,  toxicity*
Sulfuric Acids / administration & dosage,  toxicity*
Chemical
Reg. No./Substance:
0/Aerosols; 0/Gases; 0/Sulfuric Acids; 10028-15-6/Ozone; 7664-93-9/sulfuric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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