| Effects of oxygenation and luminal flow on human placenta chorionic plate blood vessel function. | |
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MedLine Citation:
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PMID: 21995599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: The human fetoplacental vasculature has been suggested to be a low resistance/high flow system, but the mechanisms by which this state is achieved are unclear. Methods: This study assessed the effects of intraluminal flow and local oxygenation on isolated human placental chorionic plate arteries and veins at term using pressure myography. Results: Chorionic plate arteries and veins exhibit myogenic tone. A small but significant arterial vasodilatation was observed following exposure to hypoxia; chorionic plate veins contracted to a similar hypoxic stimulus. Under physiological conditions of pressure and oxygenation, increased luminal flow induced vasodilatation in both chorionic plate arteries and veins. Conclusions: Human fetoplacental vascular tone can be manipulated by local physical factors. |
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Authors:
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Mark Wareing |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-14 |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: - ISSN: 1341-8076 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology. |
Affiliation:
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Maternal and Fetal Health Research Centre, School of Biomedicine, The University of Manchester, Manchester, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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