Document Detail

Effects of oxygen therapy on left ventricular function in patients with Cheyne-Stokes respiration and congestive heart failure.
MedLine Citation:
PMID:  17566188     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: Whereas both oxygen therapy and nasal continuous positive airway pressure (CPAP) decrease the apnea-hypopnea index (AHI) in patients with Cheyne-Stokes respiration (CSR) and congestive heart failure (CHF), only nasal CPAP is known to affect the left ventricular ejection fraction (LVEF). We therefore evaluated the effects of 1 month of nocturnal oxygen therapy on LVEF. METHODS: Ten patients (52 +/- 12 years) with CHF (LVEF of 12% +/- 5%) and CSR (AHI 57 +/- 61 events/hour) were studied. Polysomnograms identified CSR and were repeated on oxygen initially (oxygen night 1 [2 L/min]) and after 30 nights (oxygen night 2). LVEF was measured by radionuclide ventriculography. RESULTS: Oxygen therapy decreased the AHI from a baseline of 57 +/- 61 to 9 +/- 11 and 12 +/- 17 events per hour during oxygen nights 1 and 2, respectively (p < .05), with no difference between treatment nights. The lowest oxygen saturation increased during oxygen nights 1 and 2, from a baseline of 87% +/- 7% to 94% +/- 4% and 91% +/- 7%, respectively (p < .05), with no difference between treatment nights. The LVEF did not significantly change from a baseline of 22% +/- 11% to 19% +/- 9% after 1 month of nocturnal oxygen (p = .05). Compared to baseline, there was no change in circulation time during oxygen nights 1 and 2, from 24 +/- 8 seconds to 30 +/- 15 seconds and 23 +/- 6 seconds, respectively (p = .2). Total sleep time, sleep efficiency, and sleep architecture, when compared with baseline, remained unchanged during both oxygen therapy nights. CONCLUSIONS: Although 1 month of nocturnal oxygen therapy decreases the AHI in patients with CSR and CHF, there is no improvement in left ventricular function.
Samuel L Krachman; Thomas Nugent; Joseph Crocetti; Gilbert E D'Alonzo; Wissam Chatila
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine     Volume:  1     ISSN:  1550-9389     ISO Abbreviation:  -     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101231977     Medline TA:  J Clin Sleep Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Division of Pulmonary and Critical Care, Temple University School of Medicine, Philadelphia PA 19140, USA.
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MeSH Terms
Cheyne-Stokes Respiration / complications*,  diagnosis,  therapy*
Heart Failure / complications*,  diagnosis,  physiopathology*
Middle Aged
Oxygen / metabolism,  therapeutic use*
Severity of Illness Index
Sleep Apnea, Obstructive / complications*,  diagnosis,  therapy*
Time Factors
Ventricular Dysfunction, Left / complications*,  diagnosis,  physiopathology*
Reg. No./Substance:

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