Document Detail

Effects of oxygen and nitric oxide in oxygen on pulmonary arterial pressures of children with congenital cardiac defects.
MedLine Citation:
PMID:  8662048     Owner:  NLM     Status:  MEDLINE    
Inhaled nitric oxide is a specific pulmonary vasodilator. This study was undertaken to assess the effect on pulmonary arterial pressure of administering 100% oxygen compared with nitric oxide in oxygen. Thirteen mechanically ventilated children undergoing routine cardiac catheterization for the investigation of congenital heart disease were studied. Pulmonary arterial pressures were measured during inhalation of 30% oxygen (baseline), 100% oxygen, and nitric oxide (40 parts per million) in oxygen. In addition, in six children the pulmonary/systemic blood flow ratio and pulmonary vascular resistance were calculated using oxygen content, an assumed value for oxygen uptake, and the Fick principle. Results were compared using analysis of variance and the Wilcoxon signed-rank test. Pulmonary arterial pressure decreased from a mean value of 29.5 mmHg (SD 15.1) to 25.6 mmHg (SD 9.3), p = 0.048, after increasing the inspired oxygen fraction from 0.3 to 1.0. The addition of nitric oxide caused a further reduction to 22.9 mmHg (SD 7.9), p = 0.0001. There was no change in systemic arterial pressure or heart rate during the study period, but a small increase occurred in the mean methemoglobin level (1.1% to 1.3%) p = 0.039. Changes in the pulmonary/systemic blood flow ratio and pulmonary vascular resistance (n = 6) were not significant. Nitric oxide in oxygen appears to be a more potent pulmonary vasodilator than oxygen alone in pediatric patients with congenital cardiac defects.
K G Allman; J D Young; D Carapiet; J E Stevens; I Ostman-Smith; L N Archer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric cardiology     Volume:  17     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-02-07     Completed Date:  1997-02-07     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Nuffield Department of Anesthetics, John Radcliffe Hospital, Oxford, UK.
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MeSH Terms
Blood Pressure / drug effects
Child, Preschool
Heart Defects, Congenital / physiopathology*
Heart Septal Defects, Atrial / physiopathology
Heart Septal Defects, Ventricular / physiopathology
Nitric Oxide / pharmacology*
Oxygen / pharmacology*
Pulmonary Artery / drug effects,  physiology*
Vascular Resistance / drug effects
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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