| Effects of oxygen and misonidazole on cell transformation and cell killing in C3H 10T1/2 cells by X rays in vitro. | |
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MedLine Citation:
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PMID: 6494435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of oxygen (air) and misonidazole on the transformation and killing of 10T1/2 cells by X rays were examined. The oxygen effect for the cell transformation end point was very similar to that for cell killing. Misonidazole enhanced both cell killing and cell transformation to a similar extent. The enhancement of both end points by misonidazole occurred only in the absence of oxygen during irradiation and was of lesser magnitude than that observed for oxygen. These results demonstrate that the radiation chemical processes leading to cell killing and cell transformation, respectively, are affected similarly by these two enhancers of radiation action. |
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Authors:
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J Borsa; M D Sargent; M Einspenner; E I Azzam; G P Raaphorst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiation research Volume: 100 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-23 Completed Date: 1984-11-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 96-103 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Anaerobiosis Animals Cell Line Cell Survival / drug effects, radiation effects* Cell Transformation, Neoplastic / drug effects, radiation effects* Dose-Response Relationship, Radiation Mice Mice, Inbred C3H Misonidazole / pharmacology* Nitroimidazoles / pharmacology* Oxygen / physiology* Radiation-Sensitizing Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Nitroimidazoles; 0/Radiation-Sensitizing Agents; 13551-87-6/Misonidazole; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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