Document Detail


Effects of oxygen on exercise-induced increase of pulmonary arterial pressure in idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  19382532     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a severe disease with no known effective therapy. Patients with IPF may develop severe increase of pulmonary arterial pressure (PAP) on exercise, the mechanisms of which is not clearly identified. OBJECTIVES: To determine whether oxygen may correct the increase of PAP developed during exercise in patients with IPF. PATIENTS AND METHODS: We performed a prospective study on patients with IPF and no hypoxaemia at rest. The absence of pulmonary hypertension (PH) at rest was confirmed by echocardiography (systolic PAP <35 mmHg). Eight patients underwent echocardiography during exercise in air and with oxygen (to maintain saturation of at least 94%). Right ventricle-right atrium gradient and cardiac output were measured at rest, after each increment and at peak. We then compared the echocardiographic results obtained for air and oxygen. RESULTS: All patients developed significant increase of SPAP on exercise (73 +/- 14 mmHg in air). Oxygen did not significantly improve SPAP on exercise (SPAP: 76 +/- 15 mmHg). Echocardiographic characteristics were similar between air and oxygen except for exercise tolerance in term of workload (p=0.045) and endurance (p=0.017). Resting pulmonary function tests did not predict the occurrence of increase of PAP on exercise. CONCLUSION: Our results demonstrate that oxygen does not improve exercise-induced increase of PAP in patients with IPF and support the hypothesis that hypoxic vaso-constriction is not the main mechanism of acute increase of PAP during exercise.
Authors:
S Pouwels-Fry; S Pouwels; C Fournier; A Duchemin; I Tillie-Leblond; T Le Tourneau; B Wallaert
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders     Volume:  25     ISSN:  1124-0490     ISO Abbreviation:  Sarcoidosis Vasc Diffuse Lung Dis     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610928     Medline TA:  Sarcoidosis Vasc Diffuse Lung Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Clinique des Maladies Respiratoires, Centre de Compétence Maladies Orphelines Pulmonaires, University Hospital, CHRU, Lille, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Echocardiography, Doppler
Exercise Therapy / adverse effects*
Female
Follow-Up Studies
Heart Ventricles / physiopathology,  ultrasonography
Humans
Hypertension, Pulmonary / etiology*,  metabolism,  physiopathology
Idiopathic Pulmonary Fibrosis / metabolism,  physiopathology,  rehabilitation*
Male
Oxygen Consumption / physiology*
Prognosis
Prospective Studies
Pulmonary Wedge Pressure / physiology*
Ventricular Function, Right / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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