| Effects of oxygen breathing on pulmonary vascular input impedance in patients with pulmonary hypertension. | |
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MedLine Citation:
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PMID: 6825485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of oxygen breathing on the stiffness of the large pulmonary artery has not been elucidated. We analyzed the proximal pulmonary arterial impedance with a multisensor catheter in ten patients with pulmonary arterial hypertension (PAH), eight patients with pulmonary venous hypertension, and six control subjects. The stiffness of the vessel was quantified by the characteristic impedance (Zo) and compared with the plasma norepinephrine level. Ten minutes of high-oxygen breathing decreased the Zo (from 78 +/- 18 to 57 +/- 14 dynes.sec.cm-5, p less than 0.01) and pulmonary arterial resistance in all the cases with PAH. In this group, norepinephrine also decreased (from 381 +/- 89 to 319 +/- 77 pg/ml, p less than 0.01) following the correction of hypoxemia. Yet, those parameters did not change in the other two groups. These results indicate that in patients with PAH, oxygen breathing can reduce the stiffness of the main pulmonary artery because of the sympatholytic effect. |
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Authors:
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T Haneda; T Nakajima; K Shirato; S Onodera; T Takishima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 83 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 520-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Hemodynamics Humans Hypertension, Pulmonary / physiopathology* Norepinephrine / blood Oxygen* / blood Oxygen Inhalation Therapy Pulmonary Artery / physiopathology* Sympathetic Nervous System / physiopathology Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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