Document Detail


Effects of oxidation on changes of compressibility of bovine serum albumin.
MedLine Citation:
PMID:  15113119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The methods of ultrasound velocity and density measurements were used to study the adiabatic compressibility of bovine serum albumin (BSA) during its oxidation by the prooxidants Cu2+ and 2,2'-azobis(2-amidinopropane) hydrochloride (AAPH). We did not find changes of compressibility of BSA in the presence of copper ions at rather high molar ratio Cu2+/BSA = 0.66 mol/mol. This can be explained by binding of the Cu2+ to the binding site of BSA and thus protecting the prooxidant action of the copper. However, AAPH-mediated oxidation of BSA resulted in an increase of its apparent specific compressibility (psik/beta0). These changes could be caused by the fragmentation of the protein.
Authors:
T Hianik; P Rybár; Z Benediktyová; L Svobodová; A Hermetter
Related Documents :
9383769 - Control of culex quinquefasciatus (diptera: culicidae) with bacillus sphaericus in maro...
8528449 - Investigation of thiourea activated polyglutaraldehyde with bound ag(i) or pt(ii) as an...
2473629 - Broncho-vaxom inhibits histamine release from rat mast cells induced by compound 48/80 ...
21345159 - Steroid binding properties of the 2nd who international standard for sex hormone-bindin...
3995169 - Identification of lectin-like substances recognizing galactosyl residues of glycoconjug...
3430069 - Nonspecific high affinity binding of bile salts to carboxylester lipases.
17257619 - Induced fit, folding, and recognition of the nf-kappab-nuclear localization signals by ...
21325039 - Reversible signal binding by the pseudomonas aeruginosa quorum-sensing signal receptor ...
9425069 - Functional role of the noncatalytic domains of elongation factor tu in the interactions...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General physiology and biophysics     Volume:  22     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-04-28     Completed Date:  2004-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  467-76     Citation Subset:  IM    
Affiliation:
Department of Biophysics and Chemical Physics, Faculty of Mathematics, Physics and Computer Science, Comenius University, Bratislava, Slovakia. hianik@fmph.uniba.sk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amidines / chemistry*
Copper / chemistry*
Densitometry / methods
Elasticity
Oxidation-Reduction
Serum Albumin, Bovine / analysis,  chemistry*
Suspensions / chemistry
Ultrasonography / methods
Chemical
Reg. No./Substance:
0/Amidines; 0/Serum Albumin, Bovine; 0/Suspensions; 13217-66-8/2,2'-azobis(2-amidinopropane); 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of human erythrocytes as model cells in photodynamic therapy.
Next Document:  Developmental changes in uncoupling protein 1 and F1-ATPase subunit levels in the golden hamster bro...