| Effects of oxazolidines derived from (-) ephedrine in the rat. | |
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MedLine Citation:
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PMID: 1397980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Five oxazolidines were synthesized by reaction of (-) ephedrine with aliphatic aldehydes. The aldehydes used were formaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde and trimethylacetaldehye. 2. These five oxazolidines were tested in rats for ephedrine-like pharmacological activity using the hyperthermia and anorexia models. 3. All five oxazolidines caused significant elevation of body temperature in the hyperthermia model. The oxazolidine synthesized from (-) ephedrine and butyraldehyde caused greatest hyperthermia. 4. Four oxazolidines caused significant anorectic responses. The oxazolidine synthesized from (-) ephedrine and isobutyraldehyde caused greatest anorexia. 5. A possible tolerance to the anorectic effects of some of the compounds was observed. |
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Authors:
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R B Walker; D M Wood; M M Akmal; E Sharks |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: General pharmacology Volume: 23 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 729-32 Citation Subset: IM |
Affiliation:
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Chemistry Department, University of Arkansas, Pine Bluff 71601. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Dose-Response Relationship, Drug Drug Tolerance Eating / drug effects Ephedrine / analogs & derivatives*, pharmacology* Male Oxazoles / pharmacology* Prodrugs Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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5-S06-GM08211-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oxazoles; 0/Prodrugs; 299-42-3/Ephedrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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