Document Detail

Effects of ovariectomy and genotype on bioactive FSH in plasma and pituitary of Booroola ewes.
MedLine Citation:
PMID:  8410825     Owner:  NLM     Status:  MEDLINE    
Blood samples were collected for 13 days before and 20 days after ovariectomy from carrier (BB) and non-carrier (+ +) ewes of the Booroola FecB gene (n = 12 per genotype), at known stages of the oestrous cycle, after which the pituitary glands from these ewes were recovered. Pituitary glands were also collected from cyclic ewes (about day 12; n = 5 per genotype) to compare the effects of ovariectomy on pituitary gonadotrophins. Plasma samples and pituitary extracts were assayed for bioactive (B) FSH, immunoreactive (I) FSH and I-LH. Overall, BB ewes had significantly (P < 0.05) higher plasma I-FSH concentrations than did + + ewes before ovariectomy; the mean value was higher on 16 of the 17 days of the oestrous cycle (P < 0.01). For B-FSH, there were no overall genotypic differences, although the mean for the BB ewes was significantly higher on 13 of the 17 days of the oestrous cycle (P < 0.05), and significantly (P < 0.05) higher between days 13 and 16. No genotypic differences were noted for the plasma bioactive:immunoreactive (B:I) ratio for FSH before ovariectomy. After ovariectomy, there were significant (P < 0.001) increases in plasma for B-FSH, I-FSH and I-LH and a significant (P < 0.05) decrease in the B:I ratio for FSH, irrespective of genotype.(ABSTRACT TRUNCATED AT 250 WORDS)
D J Phillips; N L Hudson; K P McNatty
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  98     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-11-08     Completed Date:  1993-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  559-65     Citation Subset:  IM    
Wallaceville Animal Research Centre, Upper Hutt, New Zealand.
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MeSH Terms
Follicle Stimulating Hormone / analysis,  blood,  metabolism*
Luteinizing Hormone / analysis
Pituitary Gland / chemistry,  metabolism*
Sheep / blood,  genetics,  metabolism*
Reg. No./Substance:
9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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