| Effects of ovarian hormones on exercise metabolism. | |
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MedLine Citation:
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PMID: 11706286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growing evidence suggests that the ovarian hormones have major effects on lipid and carbohydrate metabolism, and may also play a major role in up-stream molecular signaling mechanisms for regulating substrate metabolism. It appears that the absence of estrogen can impair glucose uptake during exercise. In contrast, progesterone not only impairs contraction-mediated glucose uptake when solely administered, but impairs glucose uptake when physiological concentrations of both estrogen and progesterone are administered. Likewise, progesterone administered to rodents for 14 days decreases glucose transporter (GLUT) 4 protein content in skeletal muscle and adipose tissue. Furthermore removing the ovaries decreases the activity of key oxidative enzymes while estrogen treatment restores the activity of these enzymes. It appears, therefore, that estrogen increases the metabolic capacity for both carbohydrate and lipid metabolism, perhaps increasing the overall metabolic flexibility of skeletal muscle. Conversely, progesterone negates both these effects, and could therefore result in a state of relative metabolic inflexibility, similar to that observed in the metabolic syndrome. |
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Authors:
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S E Campbell; M A Febbraio |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 4 ISSN: 1363-1950 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-13 Completed Date: 2002-04-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 515-20 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Carbohydrate Metabolism* Estrogens / pharmacology, physiology* Exercise / physiology* Female Glucose Transporter Type 4 Humans Lipid Metabolism* Male Mice Monosaccharide Transport Proteins / metabolism, physiology Muscle Contraction / physiology Muscle Proteins* Muscle, Skeletal / metabolism* Ovariectomy Progesterone / pharmacology, physiology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Estrogens; 0/Glucose Transporter Type 4; 0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 0/SLC2A4 protein, human; 0/Slc2a4 protein, mouse; 0/Slc2a4 protein, rat; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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