| Effects of ornithine on neutrophil (PMN) free amino acid and alpha-keto acid profiles and immune functions in vitro. | |
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MedLine Citation:
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PMID: 15538644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the effects of ornithine on polymorphonuclear leucocyte (PMN) free amino- and alpha-keto acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Exogenous ornithine significantly increased PMN asparagine, glutamine, aspartate, glutamate, arginine, citrulline, alanine, alpha-ketoglutarate and pyruvate as intracellular ornithine increased. Concerning PMN immune function markers ornithine increased H2O2-generation and MPO activity while O2- -formation was decreased. We believe therefore that ornithine is important for affecting PMN "susceptible free amino- and alpha-keto acid pool" although the mechanisms are not yet clear. This may be one of the determinants in PMN nutrition considerably influencing and modulating PMN host defense capability. |
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Authors:
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J Mühling; M Fuchs; M Campos; J Gonter; A Sablotzki; J Engel; I D Welters; M Wolff; R Matejec; M G Dehne; T Menges; M Krüll; G Hempelmann |
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Publication Detail:
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Type: Journal Article Date: 2004-11-05 |
Journal Detail:
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Title: Amino acids Volume: 27 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 313-9 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Intensive Care Medicine, Pain Therapy, University Hospital, Justus Liebig University, Giessen, Germany. joerg.muehling@chiru.med.uni-giessen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / blood* Cells, Cultured Dose-Response Relationship, Drug Humans Hydrogen Peroxide / blood Keto Acids / blood* Male Neutrophils / drug effects, immunology*, metabolism* Ornithine / blood, pharmacology* Oxidation-Reduction Peroxidase / blood, drug effects Superoxides / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Keto Acids; 11062-77-4/Superoxides; 7006-33-9/Ornithine; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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