Document Detail

Effects of organophosphorus pesticides and their ozonation byproducts on gap junctional intercellular communication in rat liver cell line.
MedLine Citation:
PMID:  17601646     Owner:  NLM     Status:  MEDLINE    
The effects of organophosphorus pesticides (OPs), oxons and their ozonation byproducts on gap junctional intercellular communication (GJIC) on cultured BRL cell line were investigated using scrape loading and dye transfer (SL/DT) technique. The neutral red uptake assay was used to identify the non-cytotoxic levels of diazinon, parathion and methyl-parathion applied to GJIC assay. The concentration-dependent inhibition of GJIC was observed over a range of 50-350 mg/l diazinon, parathion and methyl-parathion after 90 min incubation compared with the vehicle control. However, oxons and ozonation byproducts of OPs had no inhibition effect on GJIC at any of the concentrations tested. The inhibition of GJIC by OPs was reversible after removal of the tested pesticides followed by incubation with fresh medium. The present study suggested that the ozonation treatment could be used for the detoxification of drinking water and food crops contaminated with diazinon, parathion and methyl-parathion without formation of GJIC toxicity.
Jiguo Wu; Li Lin; Tiangang Luan; Yuk Sing Chan Gilbert; Chongyu Lan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-23
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  45     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2057-63     Citation Subset:  IM    
State Key Laboratory of Biocontrol, School of Life Sciences, Zhongshan (Sun Yat-sen) University, Guangzhou 510275, PR China.
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MeSH Terms
Cell Communication / drug effects*
Cell Line
Diazinon / chemistry,  toxicity
Gap Junctions / drug effects*,  ultrastructure
Indicators and Reagents
Insecticides / chemistry*,  toxicity*
Liver / cytology*,  drug effects*
Organophosphorus Compounds / chemistry*,  toxicity*
Ozone / chemistry*
Paraoxon / analogs & derivatives,  chemistry,  toxicity
Parathion / chemistry,  toxicity
Rats, Inbred BUF
Reg. No./Substance:
0/Indicators and Reagents; 0/Insecticides; 0/Organophosphorus Compounds; 10028-15-6/Ozone; 311-45-5/Paraoxon; 333-41-5/Diazinon; 56-38-2/Parathion; 950-35-6/methylparaoxon

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