Document Detail

Effects of organochlorine chemicals on the reproductive outcome of humans who consumed contaminated Great Lakes fish: an epidemiologic consideration.
MedLine Citation:
PMID:  1908527     Owner:  NLM     Status:  MEDLINE    
Three sets of studies of the impacts of human exposure to PCB contaminated fish from the Great Lakes basin--the Michigan Sports Fisherman Cohort, the Michigan Maternal/Infant Cohort, and the Wisconsin Maternal/Infant Cohort-were evaluated using the epidemiologic criteria of Susser (1986). The studies were compared against each other, and against comparable data from other geographic locales. A total of seven major categories of exposure sequelae were evaluated. These ranged from the effects of primary exposure to contaminants upon maternal health status, to effects from secondary intrauterine fetal exposure, including alterations in birth size and gestational age, changes in neonatal health status, and effects persisting into early infancy. Results of the evaluations suggest that the causal hypothesis may be strongly affirmed for the relationship between PCB exposure and alterations in both neonatal health status and in health status in early infancy may be affirmed with reasonable certainty. While the evidence from the Michigan Maternal/Infant Cohort related to maternal exposure to PCB and infant size at birth and gestational age affirms the causal hypothesis, studies from other geographic locales tend only to be supportive. Analytic differences are likely responsible for this variation, but epidemiologically, the composite rating must be regarded as indeterminate. The relationship with observed alterations in maternal health status, composite activity ranking, and McCarthy Memory Scale deficits were also classified as indeterminate. No evidences of obvious negation were seen, although one portion of a study was disqualified because of incoherence.
W R Swain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  33     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-26     Completed Date:  1991-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-639     Citation Subset:  IM    
Eco Logic International, Inc., Ann Arbor, Michigan.
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MeSH Terms
Child Development / drug effects
Child, Preschool
Cohort Studies
Embryonic and Fetal Development / drug effects*
Food Contamination*
Food Habits
Great Lakes Region / epidemiology
Health Status
Maternal-Fetal Exchange
Milk, Human / chemistry
Polychlorinated Biphenyls / analysis,  blood,  poisoning*
Water Pollutants, Chemical / analysis,  blood,  poisoning*
Reg. No./Substance:
0/Polychlorinated Biphenyls; 0/Water Pollutants, Chemical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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