Document Detail

Effects of orally administered beta-adrenergic blockers and calcium-channel blockers on the intraocular pressure of patients with treated hypertension.
MedLine Citation:
PMID:  1359825     Owner:  NLM     Status:  MEDLINE    
Little attention has been paid to the influence of orally administered antihypertensive drugs on intraocular pressure (IOP). Therefore, we evaluated the effects of oral medications on the IOPs and visual fields of 70 patients with systemic hypertension who had no ocular symptoms and had not visited any eye hospital. In patients with systemic hypertension treated with medication, the IOP value (mean, 18.3 +/- 4.2 mmHg; age range, 63.3 +/- 11.6 years) was significantly higher than in a control group with a similar age range who were not receiving oral medication (mean, 13.7 +/- 2.0 mmHg; age range, 62.5 +/- 7.8 years). In the group in which hypertension was controlled by medication, the IOPs were lower when orally administered beta-adrenergic blockers were given than in those patients with uncontrolled hypertension. In the group to whom calcium-channel blockers were administered orally, the IOPs were not lower. Angiotensin-converting enzyme inhibitors made the visual fields worse. This study suggests a modulating influence of orally administered drugs on the IOP and visual fields, which may be affected by whether or not the patient's blood pressure is controlled.
R Suzuki; M Hanada; H Fujii; S Kurimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of ophthalmology     Volume:  24     ISSN:  0003-4886     ISO Abbreviation:  Ann Ophthalmol     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-12-10     Completed Date:  1992-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210137     Medline TA:  Ann Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Department of Ophthalmology, Yamaguchi University School of Medicine, Kogushi Ube City, Japan.
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MeSH Terms
Administration, Oral
Adrenergic beta-Antagonists / administration & dosage*,  therapeutic use
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage*,  therapeutic use
Captopril / administration & dosage
Hypertension / drug therapy*,  physiopathology
Intraocular Pressure / drug effects*
Middle Aged
Visual Fields / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Calcium Channel Blockers; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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