Document Detail

Effects of oral theophylline on sick sinus syndrome.
MedLine Citation:
PMID:  8459077     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to determine the effect of theophylline on cardiac pauses in sick sinus syndrome. BACKGROUND: Sick sinus syndrome, a relatively benign condition, is usually treated with pacemaker implantation without any proved effectiveness. Thus, an appropriate pharmacologic therapy would be useful. METHODS: Theophylline (200 to 400 mg/day for 1 month) was initially administered orally to 17 patients with sick sinus syndrome, which is manifested by sinus pauses of > 2.5 s. Eleven of the 17 patients subsequently received theophylline for an additional 8 to 37 months. Twenty-four-hour Holter recordings were obtained before treatment, at the end of 1 month of treatment and then at 6-month intervals. RESULTS: Theophylline decreased the frequency of sinus pauses from 256 +/- 230 to 23 +/- 62 pauses per 24 h and decreased the duration of the longest pauses from 4.7 +/- 1.8 to 2.2 +/- 0.97 s after 1 month of treatment. Subjective symptoms associated with cardiac pauses disappeared in 16 of 17 patients. Ventricular premature beats increased in frequency but did not last longer than two beats. Three patients experienced adverse effects. Nine of the 11 patients receiving long-term treatment had a good outcome, but 2 patients required a pacemaker because of the reappearance of long sinus pauses. CONCLUSIONS: The results suggest that oral theophylline may be beneficial for the treatment of patients with sick sinus syndrome.
D Saito; K Matsubara; H Yamanari; N Obayashi; S Uchida; K Maekawa; T Sato; K Mizuo; H Kobayashi; S Haraoka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  21     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-04-29     Completed Date:  1993-04-29     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1199-204     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, Okayama University Medical School, Japan.
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MeSH Terms
Administration, Oral
Drug Evaluation
Electrocardiography, Ambulatory / drug effects
Follow-Up Studies
Heart Rate / drug effects
Middle Aged
Sick Sinus Syndrome / drug therapy*,  physiopathology
Theophylline / administration & dosage,  pharmacology,  therapeutic use*
Treatment Outcome
Reg. No./Substance:

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