Document Detail

Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation O(2) of calf muscle during plantar flexion exercise.
MedLine Citation:
PMID:  20204841     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of a 100-mg oral single-dose administration of sarpogrelate hydrochloride (SH) on saturation O(2) (StO(2)) of calf muscle in healthy subjects experiencing simulated peripheral arterial disease (0.6 ankle brachial pressure index). Ten subjects performed three kinds of plantar flexion exercises at a work rate of 50% of maximal volunteer contraction for 4 min by using cuff occlusion ischemia,. Subjects performed a control test (C) without ischemia and SH, an ischemia test (I) without SH, and an I + SH test with ischemia. StO(2), blood pressures (BP), and heart rate (HR) were measured through all experiments. At the end of the exercise, the decrease in StO(2) from baseline in the C and I + SH tests was significantly less than that in the I test (p < 0.05, respectively). However, there were no significant differences in mean BP or HR in any of the exercise conditions. These results indicated that an oral single-dose administration of SH might improve peripheral circulation independent of any changes in BP and HR.
Masahiro Horiuchi; Koichi Okita; Shingo Takada; Masashi Omokawa; Tadashi Suga; Noriteru Morita; Kagami Hirabayashi; Takashi Yokota; Shintaro Kinugawa; Hiroyuki Tsutsui
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  662     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-6     Citation Subset:  IM    
Department of Human Care Studies, Hokkaido University of Education, Sapporo, Japan.
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MeSH Terms
Administration, Oral
Blood Pressure / drug effects,  physiology
Dose-Response Relationship, Drug
Exercise Test*
Heart Rate / drug effects,  physiology
Muscles / drug effects*,  metabolism*
Oxygen / metabolism*
Succinates / administration & dosage*,  pharmacology*
Reg. No./Substance:
0/Succinates; 7782-44-7/Oxygen; 86819-20-7/sarpogrelate

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