Document Detail

Effects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eye.
MedLine Citation:
PMID:  21832964     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: : Evaporative dry eye is associated with meibomian gland dysfunction and abnormalities of the tear film lipids. Dry eye is known to be affected positively by intake of linoleic and γ-linolenic acids and n-3 fatty acids. Oral sea buckthorn (Hippophaë rhamnoides) (SB) oil, which contains linoleic and α-linolenic acids and antioxidants, has shown beneficial effects on dry eye. The objective was to investigate whether supplementation with SB oil affects the composition of the tear film fatty acids in individuals reporting dry eye.
METHODS: : One hundred participants were randomized to this parallel, double-blind, placebo-controlled study, which 86 of them completed. The participants daily consumed 2 g of SB or placebo oil for 3 months. Tear film samples were collected at the beginning, during, and at the end of the intervention and 1 to 2 months later. Tear film fatty acids were analyzed as methyl esters by gas chromatography.
RESULTS: : There were no group differences in the changes in fatty acid proportions during the intervention (branched-chain fatty acids: P = 0.49, saturated fatty acids: P = 0.59, monounsaturated fatty acids: P = 0.53, and polyunsaturated fatty acids: P = 0.16).
CONCLUSIONS: : The results indicate that the positive effects of SB oil on dry eye are not mediated through direct effects on the tear film fatty acids. Carotenoids and tocopherols in the oil or eicosanoids produced from the fatty acids of the oil may have a positive effect on inflammation and differentiation of the meibomian gland cells.
Riikka L Järvinen; Petra S Larmo; Niko L Setälä; Baoru Yang; Janne Rk Engblom; Matti H Viitanen; Heikki P Kallio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cornea     Volume:  30     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1013-9     Citation Subset:  IM    
From the Department of *Biochemistry and Food Chemistry and †Department of Ophthalmology, University of Turku, Turku, Finland; ‡Turku School of Economics, University of Turku, Turku, Finland; §Turku City Hospital, Turku, Finland; and ¶Karolinska Institutet, Stockholm, Sweden.
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