| Effects of oral ribose on muscle metabolism during bicycle ergometer in AMPD-deficient patients. | |
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MedLine Citation:
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PMID: 1776826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three patients with AMP deaminase deficiency (AMPD deficiency) performed exercise on a bicycle ergometer with increasing work load without and with administration of ribose (3 g p.o. every 10 min, beginning 1 h before exercise until the end). The patients performed exercise until heart rate was 200 minus age. Maximum capacity was not increased by administration of ribose, but postexertional muscle stiffness and cramps disappeared almost completely in 2 of 3 AMPD-deficient patients. Plasma concentrations of lactate and inosine were increased in AMPD-deficient patients after oral administration of ribose. Our data suggest that ribose may both serve as an energy source and enhance the de novo synthesis of purine nucleotides. |
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Authors:
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D R Wagner; U Gresser; N Zöllner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 35 ISSN: 0250-6807 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-03 Completed Date: 1992-03-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 297-302 Citation Subset: IM; S |
Affiliation:
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Medizinische Poliklinik, Universität München, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP Deaminase
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deficiency* Adult Ammonia / blood Exercise / physiology* Exercise Test Humans Hypoxanthine Hypoxanthines / blood Inosine / blood Kinetics Lactates / blood Lactic Acid Male Middle Aged Muscles / drug effects, metabolism* Ribose / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 0/Lactates; 50-21-5/Lactic Acid; 50-69-1/Ribose; 58-63-9/Inosine; 68-94-0/Hypoxanthine; 7664-41-7/Ammonia; EC 3.5.4.6/AMP Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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