Document Detail

Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.
MedLine Citation:
PMID:  9168293     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effects of supplementation with oral potassium on blood pressure in humans.
DESIGN: Meta-analysis of randomized controlled trials.
DATA SOURCES: English-language articles published before July 1995.
STUDY SELECTION: Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only difference between the intervention and control conditions.
DATA EXTRACTION: Using a standardized protocol, 2 of us independently abstracted information on sample size, duration, study design, potassium dose, participant characteristics, and treatment results.
RESULTS: By means of a random-effects model, findings from individual trials were pooled, after results for each trial were weighted by the inverse of its variance. An extreme effect of potassium in lowering blood pressure was noted in 1 trial. After exclusion of this trial, potassium supplementation was associated with a significant reduction in mean (95% confidence interval) systolic and diastolic blood pressure of -3.11 mm Hg (-1.91 to -4.31 mm Hg) and -1.97 mm Hg (-0.52 to -3.42 mm Hg), respectively. Effects of treatment appeared to be enhanced in studies in which participants were concurrently exposed to a high intake of sodium.
CONCLUSIONS: Our results support the premise that low potassium intake may play an important role in the genesis of high blood pressure. Increased potassium intake should be considered as a recommendation for prevention and treatment of hypertension, especially in those who are unable to reduce their intake of sodium.
P K Whelton; J He; J A Cutler; F L Brancati; L J Appel; D Follmann; M J Klag
Related Documents :
18840623 - Sodium-lithium countertransport activity in healthy, dyslipidemic, and hypertensive ind...
6532603 - Abnormal leucocyte sodium transport in chinese patients with essential hypertension and...
8875003 - Pressure-controlled and volume-cycled mechanical ventilation.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  277     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1624-32     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Blood Pressure / drug effects*
Food, Fortified
Hypertension / prevention & control
Potassium / administration & dosage,  pharmacology*,  urine
Randomized Controlled Trials as Topic
Sodium / urine
Statistics as Topic
Grant Support
Reg. No./Substance:
9NEZ333N27/Sodium; RWP5GA015D/Potassium
Comment In:
ACP J Club. 1997 Nov-Dec;127(3):72

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Depressive symptoms and the cost of health services in HMO patients aged 65 years and older. A 4-yea...
Next Document:  Chronic myelomonocytic leukemia: from biology to therapy.