Document Detail


Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.
MedLine Citation:
PMID:  9168293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects of supplementation with oral potassium on blood pressure in humans.
DESIGN: Meta-analysis of randomized controlled trials.
DATA SOURCES: English-language articles published before July 1995.
STUDY SELECTION: Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only difference between the intervention and control conditions.
DATA EXTRACTION: Using a standardized protocol, 2 of us independently abstracted information on sample size, duration, study design, potassium dose, participant characteristics, and treatment results.
RESULTS: By means of a random-effects model, findings from individual trials were pooled, after results for each trial were weighted by the inverse of its variance. An extreme effect of potassium in lowering blood pressure was noted in 1 trial. After exclusion of this trial, potassium supplementation was associated with a significant reduction in mean (95% confidence interval) systolic and diastolic blood pressure of -3.11 mm Hg (-1.91 to -4.31 mm Hg) and -1.97 mm Hg (-0.52 to -3.42 mm Hg), respectively. Effects of treatment appeared to be enhanced in studies in which participants were concurrently exposed to a high intake of sodium.
CONCLUSIONS: Our results support the premise that low potassium intake may play an important role in the genesis of high blood pressure. Increased potassium intake should be considered as a recommendation for prevention and treatment of hypertension, especially in those who are unable to reduce their intake of sodium.
Authors:
P K Whelton; J He; J A Cutler; F L Brancati; L J Appel; D Follmann; M J Klag
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  277     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1624-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Blood Pressure / drug effects*
Food, Fortified
Humans
Hypertension / prevention & control
Potassium / administration & dosage,  pharmacology*,  urine
Randomized Controlled Trials as Topic
Sodium / urine
Statistics as Topic
Grant Support
ID/Acronym/Agency:
5 KO8 HL02642/HL/NHLBI NIH HHS; 5 MO1 RR00722/RR/NCRR NIH HHS; RR0035/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9NEZ333N27/Sodium; RWP5GA015D/Potassium
Comments/Corrections
Comment In:
ACP J Club. 1997 Nov-Dec;127(3):72

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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