| Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study. | |
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MedLine Citation:
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PMID: 18822413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-density-lipoproteins-cholesterol (HDL-C) is invertedly related to the incidence of cardiovascular events. Recent studies suggest that HDL-C directly improves endothelial function. Nicotinic acid (niacin) effectively raises serum HDL-C. We therefore hypothesized that treatment with niacin improves endothelial dysfunction in patients with coronary artery disease (CAD). One hundred seven patients with CAD were randomly assigned to double-blinded treatment for 12 weeks with extended-release (ER)-niacin 1000 mg/day (N) or placebo (C), respectively. Flow-mediated dilation (FMD) of the brachial artery, nitroglycerin-mediated endothelium-independent dilation (NMD) and serum lipid concentrations were measured before and after treatment. Triglycerides (P=0.013), low-density-lipoprotein-cholesterol (LDL-C) (P=0.013) and HDL-C (P<0.0001) were altered by N compared to C. Niacin treatment was without effect on FMD or NMD, respectively, compared to placebo. However, post-hoc subgroup analysis revealed an improvement in FMD in patients with low HDL-C at baseline (absolute change in FMD (mean+/-S.D.) N: +3.25+/-3.88%, C: +1.03+/-2.71% in low tertile HDL-C <or=45 mg/dl. P=0.047). The present findings indicate that ER-niacin treatment improves endothelial dysfunction in patients with CAD and low HDL-C, but not with normal HDL-C. |
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Authors:
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Ascan Warnholtz; Philipp Wild; Mir Abolfazl Ostad; Veronika Elsner; Fabian Stieber; Reinhard Schinzel; Ulrich Walter; Dirk Peetz; Karl Lackner; Stefan Blankenberg; Thomas Munzel |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-08-12 |
Journal Detail:
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Title: Atherosclerosis Volume: 204 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 216-21 Citation Subset: IM |
Affiliation:
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Department of Medicine II, Johannes Gutenberg-University Mainz, Mainz, Germany. warnholt@uni-mainz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Biological Markers / blood Blood Glucose / drug effects Brachial Artery / drug effects*, physiopathology, ultrasonography Cell Adhesion Molecules / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Artery Disease / blood, drug therapy*, physiopathology Delayed-Action Preparations Double-Blind Method Endothelium, Vascular / drug effects*, physiopathology Female Humans Male Microfilament Proteins / blood Middle Aged Niacin / administration & dosage* Nitroglycerin / administration & dosage Phosphoproteins / blood Phosphorylation Prospective Studies Treatment Outcome Triglycerides / blood Vasodilation / drug effects* Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Cell Adhesion Molecules; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Delayed-Action Preparations; 0/Microfilament Proteins; 0/Phosphoproteins; 0/Triglycerides; 0/Vasodilator Agents; 0/vasodilator-stimulated phosphoprotein; 55-63-0/Nitroglycerin; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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