Document Detail

Effects of oral isradipine on left ventricular function at rest and during exercise in patients with stable chronic angina: a double-blind, placebo-controlled crossover study.
MedLine Citation:
PMID:  1375679     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of a single oral dose of 5 mg of isradipine compared to placebo in a randomized, double-blind, crossover study using gated radionuclide angiography at rest and during exercise in 20 patients with stable chronic angina. Isradipine improved both anginal symptomatology and ST-segment depression during exercise, with a concomitant favorable effect on the isotopic parameters exploring systolic and diastolic left ventricular function. There was a marked increase of the ejection fraction during exercise with isradipine compared to placebo (61 +/- 14% vs. 55 +/- 15%, respectively, p less than 0.001) as well as a significant improvement in the peak ejection rate and the peak filling rate at rest [2.56 +/- 0.62 vs. 2.16 +/- 0.54 end diastolic volume (EDV) per second and 2.14 +/- 0.59 vs. 1.87 +/- 0.37 EDV/s, respectively] and during exercise (3.49 +/- 0.97 vs. 3.10 +/- 1.07 EDV/s and 4.05 +/- 1.34 vs. 3.65 +/- 1.25 EDV/s, respectively). We conclude that isradipine has a beneficial effect on the clinical and electrocardiographic signs of exercise-induced ischemia, leading to a significant improvement of the systolic and diastolic parameters of left ventricular function. Therefore, isradipine is potentially a useful treatment for patients with exertional angina and hypertension, alone or associated with beta blocker medication.
J Delonca; P Kipfer; A Righetti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  19     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-26     Completed Date:  1992-06-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Cardiology Center, University Hospital, Geneva, Switzerland.
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MeSH Terms
Angina Pectoris / drug therapy*,  physiopathology,  radionuclide imaging
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Dihydropyridines / therapeutic use*
Double-Blind Method
Electrocardiography / drug effects
Exercise / physiology*
Gated Blood-Pool Imaging
Heart / radionuclide imaging
Heart Rate / drug effects
Hemodynamics / drug effects
Middle Aged
Rest / physiology*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 75695-93-1/Isradipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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