Document Detail

Effects of oral and intramuscular vitamin K prophylaxis on vitamin K1, PIVKA-II, and clotting factors in breast fed infants.
MedLine Citation:
PMID:  1444522     Owner:  NLM     Status:  MEDLINE    
A randomised clinical trial was conducted to establish the effects of oral and intramuscular administration of vitamin K at birth on plasma concentrations of vitamin K1, proteins induced by vitamin K absence (PIVKA-II), and clotting factors. Two groups of about 165 healthy breast fed infants who received at random 1 mg vitamin K1 orally or intramuscularly after birth were studied at 2 weeks and 1 and 3 months of age. Although vitamin K1 concentrations were statistically significantly higher in the intramuscular group, blood coagulability, activities of factors VII and X and PIVKA-II concentrations did not reveal any difference between the two groups. At 2 weeks of age vitamin K1 concentrations were raised compared with reported unsupplemented concentrations and no PIVKA-II was detectable. At 3 months vitamin K1 concentrations were back at unsupplemented values and PIVKA-II was detectable in 11.5% of infants. Therefore, a repeated oral prophylaxis will be necessary to completely prevent (biochemical) vitamin K deficiency beyond the age of 1 month.
E A Cornelissen; L A Kollée; R A De Abreu; J M van Baal; K Motohara; B Verbruggen; L A Monnens
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  67     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1250-4     Citation Subset:  AIM; IM    
Department of Paediatrics, University of Nijmegen, The Netherlands.
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MeSH Terms
Administration, Oral
Biological Markers*
Blood Coagulation
Breast Feeding
Infant, Newborn
Injections, Intramuscular
Protein Precursors / metabolism*
Prothrombin / metabolism*
Vitamin K / therapeutic use*
Vitamin K 1 / deficiency*
Vitamin K Deficiency / drug therapy*,  prevention & control
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 12001-79-5/Vitamin K; 53230-14-1/acarboxyprothrombin; 84-80-0/Vitamin K 1; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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