| Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by (13)C and (2)H isotopomer analysis. | |
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MedLine Citation:
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PMID: 22133096 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate hepatic glucose metabolism of diabetic induced rats after a daily oral load of insulin nanoparticles over 2 weeks. After the 2-week treatment, an oral glucose tolerance test was performed with [U-(13)C] glucose and (2)H(2)O. Plasma glucose (2)H and (13)C enrichments were quantified and the contribution of glycogenolysis and gluconeogenesis to overall glucose production were estimated. Animals with the insulin nanoparticles displayed the lowest glycemia before the oral glucose tolerance test. In all animals, 75% of the total glucose production was from gluconeogenesis and glycogen synthesis was only detected in some animals. Gluconeogenic pathway was an active contributor to hepatic glucose production and the treatment with oral delivered insulin nanoparticles did not alter this contribution, suggesting that under this treatment, protocol hepatic glucose metabolism is not the most relevant target of insulin action but instead a more generalised effect in peripheral tissues. |
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Authors:
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Catarina Pinto Reis; Ronald Neufeld; Francisco Veiga; Isabel V Figueiredo; John Jones; Ana F Soares; Patrícia Nunes; Christiane Damgé; Rui A Carvalho |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
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Title: Journal of microencapsulation Volume: - ISSN: 1464-5246 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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CBIOS, Faculty of Science and Health Technologies, ULHT , Lisbon , Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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