Document Detail

Effects of oral glucosamine hydrochloride administration on plasma free amino acid concentrations in dogs.
MedLine Citation:
PMID:  21673884     Owner:  NLM     Status:  MEDLINE    
We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.
Kazuo Azuma; Tomohiro Osaki; Takeshi Tsuka; Tomohiro Imagawa; Yoshiharu Okamoto; Yoshimori Takamori; Saburo Minami
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Publication Detail:
Type:  Journal Article     Date:  2011-04-27
Journal Detail:
Title:  Marine drugs     Volume:  9     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-15     Completed Date:  2011-11-07     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  712-8     Citation Subset:  IM    
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
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MeSH Terms
Acetylglucosamine / pharmacology
Administration, Oral
Amino Acids / blood*
Collagen Type II / biosynthesis
Glucosamine / administration & dosage,  pharmacology*
Glucose / pharmacology
Proteoglycans / biosynthesis
Reg. No./Substance:
0/Amino Acids; 0/Collagen Type II; 0/Proteoglycans; 3416-24-8/Glucosamine; 50-99-7/Glucose; 7512-17-6/Acetylglucosamine

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