| Effects of oral contraceptives on hormonal and metabolic responses during exercise. | |
| | |
MedLine Citation:
|
PMID: 1560739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study examined the influence of oral contraceptives (OC) on GH and PRL responses and on energy substrate utilization during prolonged submaximal exercise in moderately active women (21-30 yr). Eight women taking OC (OC) and eight women with normal menstrual cycles (C) performed a standardized treadmill test of 90 min at 50% maximal oxygen uptake. Blood samples were withdrawn from an indwelling venous catheter during a 2-h rest period, at 10-min intervals during exercise and at 3 and 15 min of recovery. Serum concentrations of glucose, GH, PRL, E2, and P4 were assayed. Carbohydrate and fat utilization were estimated from respiratory exchange ratios. Basal serum levels of GH, PRL, and glucose were not significantly different (P greater than 0.05) between OC and C. OC had significantly higher (P less than 0.05) serum GH levels than C at 10 and 20 min of exercise, but the integrated areas for GH responses were not different (P = 0.059). Serum PRL levels significantly decreased (P less than 0.05) during exercise, and PRL responses were similar for the two groups. OC exhibited significantly lower blood glucose levels (P less than 0.05) during exercise and utilized significantly lower total grams of carbohydrate (P less than 0.05) during exercise than C. In conclusion, OC use was associated with enhanced GH responses, lower glucose levels, and diminished carbohydrate utilization during prolonged exercise. These results indicated that OC users demonstrated a greater carbohydrate-sparing ability than eumenorrheic women, which may be related to the contra-insulin effects of GH. The lower blood glucose levels, however, suggest the sparing of carbohydrate may act to compensate for decreased hepatic glucose output, similar to animal data. |
| | |
Authors:
|
D A Bemben; R A Boileau; J M Bahr; R A Nelson; J E Misner |
Related Documents
:
|
1559299 - Growth hormone treatment of adults with growth hormone deficiency: results of a 13-mont... 20926529 - Moderate doses of hgh (0.64 mg/d) improve lipids but not cardiovascular function in gh-... 12436279 - Hormonal responses to daily strenuous walking during 4 successive days. 18334589 - Evidence for acyl-ghrelin modulation of growth hormone release in the fed state. 2110339 - Acute exertional rhabdomyolysis in hypothyroidism: the result of a reversible defect in... 21226819 - Exercise training improves physical fitness and vascular function in children with type... 2575979 - Effect of partial agonist activity on the side effects of beta-blockade in patients wit... 21228339 - A rat model of exercise-induced asthma: a nonspecific response to a specific immunogen. 18816949 - Explaining long-term exercise adherence in women who complete a structured exercise pro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: 24 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 434-41 Citation Subset: IM; S |
Affiliation:
|
Department of Animal Science, Carle Foundation, University of Illinois, Urbana 61801. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / metabolism Carbohydrate Metabolism Contraceptives, Oral, Hormonal / pharmacology* Energy Metabolism / physiology Exercise Test Female Growth Hormone / blood* Humans Lipid Metabolism Physical Exertion / drug effects, physiology* Prolactin / blood* Pulmonary Ventilation / physiology Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Contraceptives, Oral, Hormonal; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of training on insulin secretion from single pancreatic beta cells.
Next Document: Plasma zinc uptake from a supplement during submaximal running.