Document Detail

Effects of oral contraceptives on hormonal and metabolic responses during exercise.
MedLine Citation:
PMID:  1560739     Owner:  NLM     Status:  MEDLINE    
This study examined the influence of oral contraceptives (OC) on GH and PRL responses and on energy substrate utilization during prolonged submaximal exercise in moderately active women (21-30 yr). Eight women taking OC (OC) and eight women with normal menstrual cycles (C) performed a standardized treadmill test of 90 min at 50% maximal oxygen uptake. Blood samples were withdrawn from an indwelling venous catheter during a 2-h rest period, at 10-min intervals during exercise and at 3 and 15 min of recovery. Serum concentrations of glucose, GH, PRL, E2, and P4 were assayed. Carbohydrate and fat utilization were estimated from respiratory exchange ratios. Basal serum levels of GH, PRL, and glucose were not significantly different (P greater than 0.05) between OC and C. OC had significantly higher (P less than 0.05) serum GH levels than C at 10 and 20 min of exercise, but the integrated areas for GH responses were not different (P = 0.059). Serum PRL levels significantly decreased (P less than 0.05) during exercise, and PRL responses were similar for the two groups. OC exhibited significantly lower blood glucose levels (P less than 0.05) during exercise and utilized significantly lower total grams of carbohydrate (P less than 0.05) during exercise than C. In conclusion, OC use was associated with enhanced GH responses, lower glucose levels, and diminished carbohydrate utilization during prolonged exercise. These results indicated that OC users demonstrated a greater carbohydrate-sparing ability than eumenorrheic women, which may be related to the contra-insulin effects of GH. The lower blood glucose levels, however, suggest the sparing of carbohydrate may act to compensate for decreased hepatic glucose output, similar to animal data.
D A Bemben; R A Boileau; J M Bahr; R A Nelson; J E Misner
Related Documents :
2108059 - Sperm counts and reproductive hormones in male marathoners and lean controls.
9480969 - Upper airway muscle activity in normal women: influence of hormonal status.
25025619 - The effect of training intensity on voluntary isometric strength improvement.
511939 - Characteristics of the polar assembly and disassembly of microtubules observed in vitro...
21226819 - Exercise training improves physical fitness and vascular function in children with type...
17961919 - Influence of physical training on the syrian hamster's melatonin rhythm.
24471129 - Effects of a pre-exercise meal on plasma growth hormone response and fat oxidation duri...
12704089 - How does airway inflammation modulate asthmatic airway constriction? an antigen challen...
1594419 - Influence of selected reinforcers on the cardiorespiratory exercise behavior of profoun...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  24     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  434-41     Citation Subset:  IM; S    
Department of Animal Science, Carle Foundation, University of Illinois, Urbana 61801.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism
Carbohydrate Metabolism
Contraceptives, Oral, Hormonal / pharmacology*
Energy Metabolism / physiology
Exercise Test
Growth Hormone / blood*
Lipid Metabolism
Physical Exertion / drug effects,  physiology*
Prolactin / blood*
Pulmonary Ventilation / physiology
Retrospective Studies
Reg. No./Substance:
0/Blood Glucose; 0/Contraceptives, Oral, Hormonal; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of training on insulin secretion from single pancreatic beta cells.
Next Document:  Plasma zinc uptake from a supplement during submaximal running.