Document Detail

Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise.
MedLine Citation:
PMID:  12391078     Owner:  NLM     Status:  MEDLINE    
We examined the effects of oral contraceptives (OC) on glucose flux and whole body substrate oxidation rates during rest (90 min) and two exercise intensities [60-min leg ergometer cycling at 45 and 65% peak O(2) uptake (Vo(2 peak))]. Eight healthy, eumenorrheic women were studied during the follicular and luteal phases before OC and the inactive and high-dose phases after 4 mo of a low-dose, triphasic OC. Subjects were studied in the morning 3 h after a standardized (308 kcal) breakfast. There were significant reductions in glucose rates of appearance and disappearance during exercise of both intensities with OC but not rest. There were no phase effects on substrate oxidation during rest or exercise. These results are interpreted to mean that, in women fed several hours before study, 1) OC decreases glucose flux, but not overall carbohydrate and lipid oxidation rates during moderate-intensity exercise; and 2) synthetic ovarian hormone analogs in the doses contained in OC have greater metabolic effects on glucose metabolism during exercise than do endogenous ovarian hormones.
Sang-Hoon Suh; Gretchen A Casazza; Michael A Horning; Benjamin F Miller; George A Brooks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2002-09-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-06-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-94     Citation Subset:  IM    
Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, 94720-3140, USA.
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MeSH Terms
Blood Glucose / analysis
Contraceptives, Oral / pharmacology*
Estradiol / blood
Exercise / physiology*
Glucagon / blood
Glucose / metabolism*
Insulin / blood
Lactates / blood
Longitudinal Studies
Oxidation-Reduction / drug effects
Progesterone / blood
Pulmonary Gas Exchange / drug effects
Random Allocation
Rest / physiology
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Contraceptives, Oral; 0/Insulin; 0/Lactates; 50-28-2/Estradiol; 50-99-7/Glucose; 57-83-0/Progesterone; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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