| Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise. | |
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MedLine Citation:
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PMID: 12391078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of oral contraceptives (OC) on glucose flux and whole body substrate oxidation rates during rest (90 min) and two exercise intensities [60-min leg ergometer cycling at 45 and 65% peak O(2) uptake (Vo(2 peak))]. Eight healthy, eumenorrheic women were studied during the follicular and luteal phases before OC and the inactive and high-dose phases after 4 mo of a low-dose, triphasic OC. Subjects were studied in the morning 3 h after a standardized (308 kcal) breakfast. There were significant reductions in glucose rates of appearance and disappearance during exercise of both intensities with OC but not rest. There were no phase effects on substrate oxidation during rest or exercise. These results are interpreted to mean that, in women fed several hours before study, 1) OC decreases glucose flux, but not overall carbohydrate and lipid oxidation rates during moderate-intensity exercise; and 2) synthetic ovarian hormone analogs in the doses contained in OC have greater metabolic effects on glucose metabolism during exercise than do endogenous ovarian hormones. |
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Authors:
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Sang-Hoon Suh; Gretchen A Casazza; Michael A Horning; Benjamin F Miller; George A Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2002-09-20 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 94 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-17 Completed Date: 2003-06-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 285-94 Citation Subset: IM |
Affiliation:
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Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, 94720-3140, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bicycling Blood Glucose / analysis Contraceptives, Oral / pharmacology* Estradiol / blood Exercise / physiology* Female Glucagon / blood Glucose / metabolism* Humans Insulin / blood Kinetics Lactates / blood Longitudinal Studies Oxidation-Reduction / drug effects Progesterone / blood Pulmonary Gas Exchange / drug effects Random Allocation Rest / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AR-42906/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Contraceptives, Oral; 0/Lactates; 11061-68-0/Insulin; 50-28-2/Estradiol; 50-99-7/Glucose; 57-83-0/Progesterone; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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