| Effects of the oral contraceptive pill cycle on physiological responses to hypoxic exercise. | |
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MedLine Citation:
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PMID: 12713713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test whether the oral contraceptive pill cycle affects endocrine and metabolic responses to hypoxic (fraction of inspired oxygen = 13%, P(IO2): 95 mmHg; H) versus normoxic (P(IO2):153 mmHg; N) exercise, we examined eight women (28 +/- 1.2 yr) during the third (PILL) and placebo (PLA) weeks of their monthly oral contraceptive pill cycle. Cardiopulmonary, metabolic, and neuroendocrine measurements were taken before, during, and after three 5-min consecutive workloads at 30%, 45%, and 60% of normoxic V(O2peak) in H and N trials. Heart rate response to exercise was greater in H versus N, but was not different between PILL and PLA. Lactate levels were significantly greater during exercise, and both lactate and glucose levels were significantly greater for 30 min after exercise in H versus N (p < 0.0001). When expressed relative to baseline, lactate levels were lower in PILL versus PLA, but glucose was greater in PILL versus PLA (p < 0.001). Cortisol levels were also significantly greater in PILL versus PLA (p < 0.001). Norepinephrine levels were significantly increased during exercise (p < 0.0001) and in H versus N (p < 0.0001). However, epinephrine levels were not different over time or with trial. Thus, the presence of circulating estradiol and progesterone during the PILL phase reduces glucose and lactate responses to hypoxic exercise. |
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Authors:
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Darleen A Sandoval; Kathleen S Matt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: High altitude medicine & biology Volume: 4 ISSN: 1527-0297 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-04-25 Completed Date: 2003-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 61-72 Citation Subset: IM; S |
Affiliation:
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Exercise Science Department, Arizona State University, Tempe, AZ, USA. darlene.sandoval@mcmail.vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anoxia / physiopathology* Blood Glucose / drug effects* Blood Pressure / physiology Contraceptives, Oral / pharmacology* Epinephrine / blood Exercise / physiology* Exercise Test Female Heart Rate / physiology Humans Hydrocortisone / blood Lactic Acid / blood* Norepinephrine / blood Oxygen Consumption / physiology Pulmonary Gas Exchange / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Contraceptives, Oral; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
| Investigator | |
Investigator/Affiliation:
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D A Sandoval / ACSM, Tempe, AZ |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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