| Effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on lipid metabolism during 1 year of conventional or extended-cycle use. | |
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MedLine Citation:
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PMID: 20004274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of extended regimens of combined oral contraceptives (COC) on lipid parameters are largely unknown. The present study compared the effects of a COC containing 30 mcg ethinyl estradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year. STUDY DESIGN: Lipid parameters were measured in 59 women treated with EE/DNG either conventionally (21+7 days) or in extended-cycle regimen (84+7 days). Blood samples were taken in a control cycle and at 3 and 12 months of treatment. RESULTS: The mean levels of total cholesterol, HDL cholesterol and HDL(2) cholesterol underwent modest to moderate significant increases over time, while the significant increase in triglycerides and VLDL cholesterol was more pronounced with both regimens. LDL cholesterol decreased slightly in both regimen groups, whereas lipoprotein(a) was transiently decreased at 3 months only in the extended-cycle group. The changes reached a steady-state at latest at 3 months, but did not exceed the given normal ranges for any of the parameters. Notably, except for lipoprotein(a), the changes in mean lipid levels were not significantly different in the conventional and the extended-cycle regimen at 3 or 12 months of treatment. CONCLUSION: Use of EE/DNG in conventional or extended-cycle regimen resulted in comparable changes of lipid parameters. |
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Authors:
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Inka Wiegratz; Skadi Stahlberg; Torsten Manthey; Nicole S?nger; Katrin Mittmann; Ernesta Palombo-Kinne; Uwe Mellinger; Evelyn Lange; Herbert Kuhl |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contraception Volume: 81 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 57-61 Citation Subset: IM |
Affiliation:
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Center of Obstetrics and Gynecology, University Hospital of Frankfurt, D-60590 Frankfurt, Germany. inkawiegratz@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cholesterol / blood* Contraceptives, Oral, Combined / administration & dosage Drug Administration Schedule Ethinyl Estradiol / administration & dosage* Female Humans Intention to Treat Analysis Lipid Metabolism / drug effects* Nandrolone / administration & dosage, analogs & derivatives* Patient Selection Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Combined; 0/Triglycerides; 434-22-0/Nandrolone; 57-63-6/Ethinyl Estradiol; 57-88-5/Cholesterol; 65928-58-7/dienogest |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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