| Effects of oral clonidine premedication on haemodynamic response to laryngoscopy and tracheal intubation: a clinical trial. | |
| | |
MedLine Citation:
|
PMID: 21313892 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The objective of this study was to evaluate the efficacy of pre-anesthetic orally administration of clonidine on pulse rate and blood stress response to laryngoscopy and tracheal intubation. In a double-blinded, randomized study, 274 ASA I and II subjects with age of 18 to 45 years scheduled for elective surgery under general anesthesia were enrolled. They were randomly allocated to receive oral clonidine (0.2 mg) or placebo as premedication 90-120 min before surgery. All the patients received Succinylcholine (1.5 mg kg(-1)) after induction of anesthesia with Fentanyl (50 microg) and Thiopentone (5 mg kg(-1)). The anesthesia was maintained with halothane (1.5 Mac) in 50% mixture of N2O/O2. Heart rate and systolic blood pressure were recorded before, immediately after and then every 5 min after intubation until 20 min. The Clonidine group showed a significant superiority over placebo in the prevention of increase in systolic blood pressure as well as heart rate over the intubation. A significant difference was observed in both heart rate and systolic blood pressures were significantly higher in Control group at three subsequent measurements following intubation. The results of this study suggest that orally administered clonidine in preanesthetic period, provides more haemodynamic stability and attenuates the stress response to laryngoscopy and intubation. |
| | |
Authors:
|
H Talebi; A Nourozi; S Fateh; A Mohammadzadeh; P Eghtesadi-Araghi; S Jabbari; M Kalantarian |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pakistan journal of biological sciences: PJBS Volume: 13 ISSN: 1028-8880 ISO Abbreviation: Pak. J. Biol. Sci. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101247723 Medline TA: Pak J Biol Sci Country: Pakistan |
Other Details:
|
Languages: eng Pagination: 1146-50 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Arak University of Medical Sciences, Arak, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of flax seeds and date palm leaves extracts on serum concentrations of glucose and lipids in ...
Next Document: Production of desferrioxamine B (Desferal) using corn steep liquor in Streptomyces pilosus.