Document Detail


Effects of oral cetirizine, a selective H1 antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma.
MedLine Citation:
PMID:  1968919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protective efficacy of oral cetirizine, a selective and potent H1-receptor antagonist, against the immediate bronchoconstrictive response to allergen inhalation and exercise challenge was evaluated in 16 subjects with stable, predominantly mild asthma. The subjects underwent double-blind, crossover pretreatments in randomized order in two separate protocols with (1) three daily oral doses of 20 mg of cetirizine and placebo, followed by allergen inhalation, and (2) single oral doses of cetirizine (5, 10, and 20 mg), albuterol (4 mg), and placebo, followed by exercise with cold-air inhalation. Cetirizine failed to decrease bronchial sensitivity to inhaled allergen in eight of 10 subjects. Neither cetirizine nor albuterol uniformly inhibited exercise-induced bronchoconstriction. Serum concentrations of cetirizine were consistent with systemic H1-blocking activity. Modest bronchodilation occurred after administration of cetirizine and albuterol before exercise but not after the third dose of cetirizine in the allergen protocol. One subject developed moderate drowsiness during multiple dosing with cetirizine. Thus, cetirizine, in the doses studied, is not uniformly effective in preventing allergen- or exercise-induced bronchoconstriction. Histamine is one of many mediators participating in immediate asthmatic responses, and selective H1 antagonists do not completely block these airway events. However, cetirizine may still clinically benefit some patients with asthma, such as patients with allergic rhinitis or urticaria.
Authors:
H Gong; D P Tashkin; B Dauphinee; B Djahed; T C Wu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  85     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-23     Completed Date:  1990-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  632-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of California-Los Angeles Medical Center 90024-1690.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Albuterol / administration & dosage
Allergens / adverse effects*
Asthma / drug therapy*,  etiology,  physiopathology
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Bronchi / drug effects*,  physiopathology
Bronchial Provocation Tests
Cetirizine
Constriction, Pathologic / drug therapy,  physiopathology
Dose-Response Relationship, Drug
Double-Blind Method
Forced Expiratory Volume / drug effects,  physiology
Histamine H1 Antagonists / administration & dosage*,  adverse effects
Humans
Hydroxyzine / administration & dosage,  adverse effects,  analogs & derivatives*
Peak Expiratory Flow Rate / drug effects,  physiology
Randomized Controlled Trials as Topic
Chemical
Reg. No./Substance:
0/Allergens; 0/Histamine H1 Antagonists; 18559-94-9/Albuterol; 68-88-2/Hydroxyzine; 83881-51-0/Cetirizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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