Document Detail

Effects of oral administration of streptococcal preparation OK-432 on thoracic duct lymphocytes.
MedLine Citation:
PMID:  3502615     Owner:  NLM     Status:  MEDLINE    
One KE of streptococcal preparation OK-432 (PIC) was given orally to 6-week old male Wistar-Imamichi rats twice weekly, and control animals received comparable volumes of saline alone. Samples of thoracic duct lymph and posterior vena caval blood were collected prior to and 4 and 8 weeks following PIC. The T cell count of thoracic duct lymphocytes was about three times greater than that of venous blood specimens, and increased significantly in animals following PIC. Controls showed only a slight increase followed by a decrease, so that by 8 weeks of treatment with PIC, the thoracic duct T cell count revealed a significantly greater number in the PIC group than in the controls. In addition, after 8 weeks the per cent T cell subpopulation in thoracic duct lymph increased significantly in the treated group, but it declined in the control group. Concerning T cell subsets in thoracic duct lymphocytes, the percentage of suppressor/cytotoxic T cells showed a significant elevation in the control group after 4 weeks compared with the treated group. No other blood or lymph variables reached statistical significance in this respect.
H Hanaue; D Y Kim; T Machimura; M Tsukui; M Kubota; T Kurosawa; J Shikata; Y Kondoh; K Ogoshi; H Makuuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  12     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-09-01     Completed Date:  1988-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Department of Surgery, Tokai University Oiso Hospital, Japan.
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MeSH Terms
Administration, Oral
Biological Products / pharmacology*
Leukocyte Count
Picibanil / pharmacology*
Rats, Inbred Strains
T-Lymphocytes / classification,  drug effects*
Thoracic Duct
Reg. No./Substance:
0/Biological Products; 39325-01-4/Picibanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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