| Effects of oral administration of streptococcal preparation OK-432 on thoracic duct lymphocytes. | |
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MedLine Citation:
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PMID: 3502615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One KE of streptococcal preparation OK-432 (PIC) was given orally to 6-week old male Wistar-Imamichi rats twice weekly, and control animals received comparable volumes of saline alone. Samples of thoracic duct lymph and posterior vena caval blood were collected prior to and 4 and 8 weeks following PIC. The T cell count of thoracic duct lymphocytes was about three times greater than that of venous blood specimens, and increased significantly in animals following PIC. Controls showed only a slight increase followed by a decrease, so that by 8 weeks of treatment with PIC, the thoracic duct T cell count revealed a significantly greater number in the PIC group than in the controls. In addition, after 8 weeks the per cent T cell subpopulation in thoracic duct lymph increased significantly in the treated group, but it declined in the control group. Concerning T cell subsets in thoracic duct lymphocytes, the percentage of suppressor/cytotoxic T cells showed a significant elevation in the control group after 4 weeks compared with the treated group. No other blood or lymph variables reached statistical significance in this respect. |
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Authors:
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H Hanaue; D Y Kim; T Machimura; M Tsukui; M Kubota; T Kurosawa; J Shikata; Y Kondoh; K Ogoshi; H Makuuchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tokai journal of experimental and clinical medicine Volume: 12 ISSN: 0385-0005 ISO Abbreviation: Tokai J. Exp. Clin. Med. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1988-09-01 Completed Date: 1988-09-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7704186 Medline TA: Tokai J Exp Clin Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Department of Surgery, Tokai University Oiso Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Biological Products / pharmacology* Leukocyte Count Male Picibanil / pharmacology* Rats Rats, Inbred Strains T-Lymphocytes / classification, drug effects* Thoracic Duct |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 39325-01-4/Picibanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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